AMPD2 - AMP deaminase 2 - human protein (Function)
 
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AMPD2 »  AMP deaminase 2   [ EC 3.5.4.6 ]
 
Protein also known as:  AMP deaminase isoform L.
Gene name:  AMPD2
Entry whose protein(s) existence is based on evidence at protein level
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1 31 5
GENE REF ISO

Function

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Overview 
AMP deaminase plays a critical role in energy metabolism.  
  • CuratedUniProtKB
GO molecular function 
AMP deaminase activitydefinition[GO:0003876]  
2
  • IGIMGI
  • NASUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Energy homeostasisdefinition[GO:0097009]  
1
  • IGIMGI
IMP biosynthetic processdefinition[GO:0006188]  
1
  • IGIMGI
IMP salvagedefinition[GO:0032264]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.4.6: AMP + H(2)O IMP + NH(3).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+271  
Purine metabolism  hsa00230+271  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Nucleotide metabolism  definition   [KW-0546]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q01433
Other
GeneWiki: AMPD2
GenomeRNAi: 271
PRO: PR:Q01433