ANK2 - Ankyrin-2 - human protein (Function)
 
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ANK2 »  Ankyrin-2  (ANK-2)
 
Protein also known as:  Non-erythroid ankyrin.
Gene name:  ANK2
Entry whose protein(s) existence is based on evidence at protein level
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1 82 4
GENE REF ISO

Function

 show evidences
Overview 
In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ankyrin (ankyrin) family  8.A.28.1.1  
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
  • ISSOrtholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Ion channel bindingdefinition[GO:0044325]  
2
  • IPIBHF-UCL
  • ISSOrtholog Curator
Potassium channel regulator activitydefinition[GO:0015459] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIBHF-UCL
  • IPIIntAct
  • IPIUniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
  • ISSOrtholog Curator
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Spectrin bindingdefinition[GO:0030507]  
1
  • IPIBHF-UCL
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAOrtholog Compara
GO biological process 
Atrial cardiac muscle cell action potentialdefinition[GO:0086014]  
3
  • IMPBHF-UCL
Atrial cardiac muscle cell to AV node cell communicationdefinition[GO:0086066]  
  • ISSOrtholog Curator
Atrial septum developmentdefinition[GO:0003283]  
1
  • IMPBHF-UCL
Cardiac muscle contractiondefinition[GO:0060048] silver  
  • IEAOrtholog Compara
Cellular calcium ion homeostasisdefinition[GO:0006874]  
  • ISSOrtholog Curator
Cellular protein localizationdefinition[GO:0034613]  
2
  • IGIBHF-UCL
Membrane depolarization during SA node cell action potentialdefinition[GO:0086046]  
1
  • TASBHF-UCL
Paranodal junction assemblydefinition[GO:0030913] silver  
  • IEAOrtholog Compara
Positive regulation of calcium ion transmembrane transporter activitydefinition[GO:1901021]  
  • ISSOrtholog Curator
Positive regulation of calcium ion transportdefinition[GO:0051928]  
  • ISSOrtholog Curator
Positive regulation of cation channel activitydefinition[GO:2001259]  
  • ISSOrtholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IGIBHF-UCL
Positive regulation of potassium ion transmembrane transporter activitydefinition[GO:1901018]  
  • ISSOrtholog Curator
Positive regulation of potassium ion transportdefinition[GO:0043268]  
  • ISSOrtholog Curator
Protein localization to cell surfacedefinition[GO:0034394]  
  • ISSOrtholog Curator
Protein localization to endoplasmic reticulumdefinition[GO:0070972]  
1
  • IGIBHF-UCL
Protein localization to M-banddefinition[GO:0036309]  
  • ISSOrtholog Curator
Protein localization to organelledefinition[GO:0033365]  
1
  • IGIBHF-UCL
Protein localization to plasma membranedefinition[GO:0072659]  
2
  • ISSBHF-UCL
  • ISSOrtholog Curator
Protein localization to T-tubuledefinition[GO:0036371]  
  • ISSOrtholog Curator
Protein stabilizationdefinition[GO:0050821]  
1
  • ISSBHF-UCL
Protein targeting to plasma membranedefinition[GO:0072661] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transmembrane transporter activitydefinition[GO:1901019]  
1
  • ISSBHF-UCL
Regulation of calcium ion transportdefinition[GO:0051924]  
2
  • IGIBHF-UCL
Regulation of cardiac muscle cell contractiondefinition[GO:0086004]  
1
  • IGIBHF-UCL
Regulation of cardiac muscle cell membrane potentialdefinition[GO:0086036] silver  
  • IEAOrtholog Compara
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • IMPBHF-UCL
Regulation of cardiac muscle contraction by calcium ion signalingdefinition[GO:0010882]  
1
  • IMPBHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
2
  • ISSBHF-UCL
Regulation of heart ratedefinition[GO:0002027]  
1
  • IMPBHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
4
  • IMPBHF-UCL
  • ISSOrtholog Curator
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • ICBHF-UCL
Regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051279]  
1
  • IGIBHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • IMPBHF-UCL
Response to methylmercurydefinition[GO:0051597] silver  
  • IEAOrtholog Compara
SA node cell action potentialdefinition[GO:0086015]  
  • ISSOrtholog Curator
SA node cell to atrial cardiac muscle cell communicationdefinition[GO:0086070]  
3
  • IMPBHF-UCL
Sarcoplasmic reticulum calcium ion transportdefinition[GO:0070296]  
1
  • TASBHF-UCL
T-tubule organizationdefinition[GO:0033292]  
  • ISSOrtholog Curator
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
1
  • IMPBHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 287
PRO: PR:Q01484