HMGCS1 - Hydroxymethylglutaryl-CoA synthase, cytoplasmic - human protein (Function)
 
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HMGCS1 »  Hydroxymethylglutaryl-CoA synthase, cytoplasmic   [ EC 2.3.3.10 ]  (HMG-CoA synthase)
 
Protein also known as:  3-hydroxy-3-methylglutaryl coenzyme A synthase.
Gene name:  HMGCS1
Family name: HMG-CoA synthase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.  
  • CuratedUniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Hydroxymethylglutaryl-CoA synthase activitydefinition[GO:0004421]  
  • IEAEC 2 GO
Isomerase activitydefinition[GO:0016853] silver  
  • IEAOrtholog Compara
Organic acid bindingdefinition[GO:0043177] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cellular response to cholesteroldefinition[GO:0071397] silver  
  • IEAOrtholog Compara
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372] silver  
  • IEAOrtholog Compara
Isoprenoid biosynthetic processdefinition[GO:0008299] silver  
  • IEAInterPro 2 GO
Lipid metabolic processdefinition[GO:0006629]  
1
  • NASPINC
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Response to acid chemicaldefinition[GO:0001101] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to lipoprotein particledefinition[GO:0055094] silver  
  • IEAOrtholog Compara
Response to low light intensity stimulusdefinition[GO:0009645] silver  
  • IEAOrtholog Compara
Response to purine-containing compounddefinition[GO:0014074] silver  
  • IEAOrtholog Compara
Response to tellurium iondefinition[GO:0046690] silver  
  • IEAOrtholog Compara
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.3.10: Acetyl-CoA + H(2)O + acetoacetyl-CoA (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+3157  
Metabolic pathways  hsa01100+3157  
Synthesis and degradation of ketone bodies  hsa00072+3157  
Terpenoid backbone biosynthesis  hsa00900+3157  
Valine, leucine and isoleucine degradation  hsa00280+3157  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
Cholesterol biosynthesis  REACT_9405  
PPARA activates gene expression  REACT_116145  
 
More information is available from:
 

Keywords

Biological process 
Cholesterol biosynthesis  definition   [KW-0152]
Cholesterol metabolism  definition   [KW-0153]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 3157
PRO: PR:Q01581
Chemistry
GuidetoPHARMACOLOGY: 638