IFITM2 - Interferon-induced transmembrane protein 2 - human protein (Function)
 
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IFITM2 »  Interferon-induced transmembrane protein 2
 
Protein also known as:  Interferon-inducible protein 1-8D.
Gene name:  IFITM2
Family name: Capucin
Entry whose protein(s) existence is based on evidence at protein level
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1 21 1
GENE REF ISO

Function

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Overview 
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.  
8
  • UniProtKB
GO biological process 
Defense response to virusdefinition[GO:0051607]  
1
  • UniProtKB KW
Immune responsedefinition[GO:0006955]  
1
  • PINC
Negative regulation of viral entry into host celldefinition[GO:0046597]  
2
  • CACAO
  • UniProtKB
Negative regulation of viral genome replicationdefinition[GO:0045071]  
1
  • UniProtKB
Response to interferon-alphadefinition[GO:0035455]  
1
  • UniProtKB
Response to interferon-betadefinition[GO:0035456]  
1
  • UniProtKB
Response to interferon-gammadefinition[GO:0034341]  
1
  • UniProtKB
Response to virusdefinition[GO:0009615]  
3
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interferon alpha/beta signaling  REACT_25162  
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10581
PRO: PR:Q01629