CACNA1D - Voltage-dependent L-type calcium channel subunit alpha-1D - human protein (Function)
 
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References

 
CACNA1D »  Voltage-dependent L-type calcium channel subunit alpha-1D
 
Protein also known as:  Calcium channel, L type, alpha-1 polypeptide, isoform 2.
Gene name:  CACNA1D
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).  
1
  • CuratedUniProtKB
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • IPIBHF-UCL
Ankyrin bindingdefinition[GO:0030506]  
1
  • ISSBHF-UCL
Contributes to high voltage-gated calcium channel activitydefinition[GO:0008331]  
1
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Voltage-gated calcium channel activitydefinition[GO:0005245]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Voltage-gated calcium channel activity involved in cardiac muscle cell action potentialdefinition[GO:0086007]  
1
  • ICBHF-UCL
Voltage-gated calcium channel activity involved SA node cell action potentialdefinition[GO:0086059]  
1
  • IMPBHF-UCL
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
  • ISSOrtholog Curator
Calcium ion importdefinition[GO:0070509]  
1
  • IDABHF-UCL
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • ISSOrtholog Curator
Calcium ion transportdefinition[GO:0006816]  
1
  • IDAUniProtKB
Membrane depolarization during cardiac muscle cell action potentialdefinition[GO:0086012]  
1
  • ICBHF-UCL
Membrane repolarization during SA node cell action potentialdefinition[GO:0086052]  
1
  • IMPBHF-UCL
Positive regulation of calcium ion transportdefinition[GO:0051928]  
1
  • IDABHF-UCL
Regulation of atrial cardiac muscle cell membrane repolarizationdefinition[GO:0060372]  
  • ISSOrtholog Curator
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of potassium ion transmembrane transportdefinition[GO:1901379]  
  • ISSOrtholog Curator
Regulation of potassium ion transmembrane transporter activitydefinition[GO:1901016]  
  • ISSOrtholog Curator
Sensory perception of sounddefinition[GO:0007605]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+776  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+776  
Calcium signaling pathway  hsa04020+776  
Carbohydrate digestion and absorption  hsa04973+776  
Cardiac muscle contraction  hsa04260+776  
Cholinergic synapse  hsa04725+776  
Dilated cardiomyopathy  hsa05414+776  
Dopaminergic synapse  hsa04728+776  
GABAergic synapse  hsa04727+776  
Glutamatergic synapse  hsa04724+776  
GnRH signaling pathway  hsa04912+776  
Hypertrophic cardiomyopathy (HCM)  hsa05410+776  
MAPK signaling pathway  hsa04010+776  
Type II diabetes mellitus  hsa04930+776  
Vascular smooth muscle contraction  hsa04270+776  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cav1.3
GenomeRNAi: 776
PRO: PR:Q01668
Chemistry
GuidetoPHARMACOLOGY: 530