ATP2B2 - Plasma membrane calcium-transporting ATPase 2 - human protein (Function)
 
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ATP2B2 »  Plasma membrane calcium-transporting ATPase 2   [ EC 3.6.3.8 ]  (PMCA2)
 
Protein also known as:  Plasma membrane calcium ATPase isoform 2.
Gene name:  ATP2B2
Entry whose protein(s) existence is based on evidence at protein level
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1 58 8
GENE REF ISO

Function

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Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
  • IEAUniProtKB KW
Isoform  WB   Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Calcium-dependent ATPase activitydefinition[GO:0030899] silver  
  • IEAOrtholog Compara
Calcium-transporting ATPase activitydefinition[GO:0005388]  
2
  • IDAUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • IDAUniProtKB
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Isoform  WB   PDZ domain bindingdefinition[GO:0030165]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Isoform  WB   Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
2
  • IDAGOC
Auditory receptor cell stereocilium organizationdefinition[GO:0060088] silver  
  • IEAOrtholog Compara
Isoforms  WB , YB and ZB   Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • IDAGOC
Calcium ion transportdefinition[GO:0006816]  
1
  • IMPDFLAT
Isoforms  WB , YB and ZB   Cation transportdefinition[GO:0006812]  
1
  • IDAGOC
Cerebellar granule cell differentiationdefinition[GO:0021707] silver  
  • IEAOrtholog Compara
Cerebellar Purkinje cell differentiationdefinition[GO:0021702] silver  
  • IEAOrtholog Compara
cGMP metabolic processdefinition[GO:0046068] silver  
  • IEAOrtholog Compara
Cochlea developmentdefinition[GO:0090102] silver  
  • IEAOrtholog Compara
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
1
  • IMPDFLAT
Detection of mechanical stimulus involved in sensory perception of sounddefinition[GO:0050910] silver  
  • IEAOrtholog Compara
Isoforms  WB , YB and ZB   Divalent inorganic cation transportdefinition[GO:0072511]  
1
  • IDAGOC
Isoforms  WB , YB and ZB   Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Locomotiondefinition[GO:0040011] silver  
  • IEAOrtholog Compara
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Isoforms  WB , YB and ZB   Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Isoforms  WB , YB and ZB   Metal ion transportdefinition[GO:0030001]  
1
  • IDAGOC
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182]  
1
  • IDAUniProtKB
Organelle organizationdefinition[GO:0006996] silver  
  • IEAOrtholog Compara
Otolith mineralizationdefinition[GO:0045299] silver  
  • IEAOrtholog Compara
Positive regulation of calcium ion transportdefinition[GO:0051928] silver  
  • IEAOrtholog Compara
Regulation of cell sizedefinition[GO:0008361] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605]  
2
  • IMPDFLAT
  • IMPUniProtKB
Serotonin metabolic processdefinition[GO:0042428] silver  
  • IEAOrtholog Compara
Synapse organizationdefinition[GO:0050808] silver  
  • IEAOrtholog Compara
Isoforms  WB , YB and ZB   Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Transportdefinition[GO:0006810]  
2
  • IDAGOC
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+491  
Pancreatic secretion  hsa04972+491  
Salivary secretion  hsa04970+491  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2B2
GenomeRNAi: 491
PRO: PR:Q01814