POU5F1 - POU domain, class 5, transcription factor 1 - human protein (Function)
 
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Protein
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References

 
POU5F1 »  POU domain, class 5, transcription factor 1
 
Protein also known as:  Octamer-binding transcription factor 3 (OTF-3).
Gene name:  POU5F1
Entry whose protein(s) existence is based on evidence at protein level
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7 268 2
GENE REF ISO

Function

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Overview 
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IDAHGNC
miRNA bindingdefinition[GO:0035198]  
2
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAMGI
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAHGNC
Isoform  A   Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Isoform  A   Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIBHF-UCL
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Blastocyst developmentdefinition[GO:0001824]  
  • ISSOrtholog Curator
Isoform  A   BMP signaling pathway involved in heart inductiondefinition[GO:0003130]  
1
  • IMPBHF-UCL
Isoform  A   Cardiac cell fate determinationdefinition[GO:0060913]  
1
  • IDABHF-UCL
Isoform  A   Cell fate commitment involved in formation of primary germ layerdefinition[GO:0060795]  
1
  • IMPBHF-UCL
Endodermal cell fate specificationdefinition[GO:0001714]  
1
  • IDAMGI
mRNA transcription from RNA polymerase II promoterdefinition[GO:0042789]  
  • ISSOrtholog Curator
Negative regulation of gene silencing by miRNAdefinition[GO:0060965]  
1
  • IMPUniProtKB
Isoform  A   Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
1
  • IDABHF-UCL
Isoform  A   Positive regulation of SMAD protein import into nucleusdefinition[GO:0060391]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAMGI
  • IDABHF-UCL
Regulation of asymmetric cell divisiondefinition[GO:0009786]  
  • ISSOrtholog Curator
Regulation of gene expressiondefinition[GO:0010468]  
1
  • IMPUniProtKB
Isoform  A   Regulation of heart induction by regulation of canonical Wnt signaling pathwaydefinition[GO:0090081]  
1
  • IMPBHF-UCL
Isoform  A   Regulation of methylation-dependent chromatin silencingdefinition[GO:0090308]  
1
  • IDABHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAHGNC
Response to woundingdefinition[GO:0009611]  
1
  • IEPUniProtKB
Somatic stem cell maintenancedefinition[GO:0035019]  
3
  • IMPBHF-UCL
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
Note 
Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5460
PRO: PR:Q01860