COL4A3 - Collagen alpha-3(IV) chain - human protein (Function)
 
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COL4A3 »  Collagen alpha-3(IV) chain
 
Protein also known as:  Goodpasture antigen. Cleaved into:  Tumstatin.
Gene name:  COL4A3
Family name: Type IV collagen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.  
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  • UniProtKB
Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.  
1
  • UniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201] silver  
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  • InterPro 2 GO
Integrin bindingdefinition[GO:0005178]  
2
  • UniProtKB
Metalloendopeptidase inhibitor activitydefinition[GO:0008191]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Structural molecule activitydefinition[GO:0005198]  
1
  • PINC
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • UniProtKB
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Endothelial cell apoptotic processdefinition[GO:0072577]  
1
  • UniProtKB
Glomerular basement membrane developmentdefinition[GO:0032836]  
1
  • Ortholog Curator
Negative regulation of angiogenesisdefinition[GO:0016525]  
2
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • GOC
Sensory perception of sounddefinition[GO:0007605]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  R-HSA-2214320  
Assembly of collagen fibrils and other multimeric structures  R-HSA-2022090  
Collagen biosynthesis and modifying enzymes  R-HSA-1650814  
Collagen degradation  R-HSA-1442490  
ECM proteoglycans  R-HSA-3000178  
Extracellular matrix organization  R-HSA-1474244  
Integrin cell surface interactions  R-HSA-216083  
Laminin interactions  R-HSA-3000157  
NCAM1 interactions  R-HSA-419037  
Non-integrin membrane-ECM interactions  R-HSA-3000171  
Signaling by PDGF  R-HSA-186797  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Collagen_alpha-3(IV)_chain
GenomeRNAi: 1285
PRO: PR:Q01955