COL4A3 - Collagen alpha-3(IV) chain - human protein (Function)
 
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COL4A3 »  Collagen alpha-3(IV) chain
 
Cleaved into:  Tumstatin.
Gene name:  COL4A3
Family name: Type IV collagen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.  
4
  • CuratedUniProtKB
Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.  
4
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201] silver  
  • IEAInterPro 2 GO
Integrin bindingdefinition[GO:0005178]  
2
  • IDAUniProtKB
Metalloendopeptidase inhibitor activitydefinition[GO:0008191]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Structural molecule activitydefinition[GO:0005198]  
1
  • NASPINC
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDAUniProtKB
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell proliferationdefinition[GO:0008283]  
1
  • IDAUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • NASUniProtKB
Endothelial cell apoptotic processdefinition[GO:0072577]  
1
  • IDAUniProtKB
Glomerular basement membrane developmentdefinition[GO:0032836]  
  • ISSOrtholog Curator
Negative regulation of angiogenesisdefinition[GO:0016525]  
2
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • NASGOC
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  REACT_150268  
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen biosynthesis and modifying enzymes  REACT_121139  
Collagen degradation  REACT_150401  
ECM proteoglycans  REACT_163906  
Extracellular matrix organization  REACT_118779  
Integrin cell surface interactions  REACT_13552  
Laminin interactions  REACT_169262  
NCAM1 interactions  REACT_18312  
Non-integrin membrane-ECM interactions  REACT_163874  
Signaling by PDGF  REACT_16888  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Collagen_alpha-3(IV)_chain
GenomeRNAi: 1285
PRO: PR:Q01955