SLC6A3 - Sodium-dependent dopamine transporter - human protein (Function)
 
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Protein
Gene
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SLC6A3 »  Sodium-dependent dopamine transporter  (DAT)
 
Protein also known as:  Solute carrier family 6 member 3.
Gene name:  SLC6A3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
2 391 1
GENE REF ISO

Function

 show evidences
Overview 
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter:sodium symporter (nss) family  2.A.22.1.3  
GO molecular function 
Dopamine bindingdefinition[GO:0035240] silver  
1
  • Ortholog Compara
Dopamine transmembrane transporter activitydefinition[GO:0005329]  
1
  • UniProtKB
Dopamine:sodium symporter activitydefinition[GO:0005330]  
1
  • RefGenome
Monoamine transmembrane transporter activitydefinition[GO:0008504]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein N-terminus bindingdefinition[GO:0047485] silver  
1
  • Ortholog Compara
GO biological process 
Adenohypophysis developmentdefinition[GO:0021984] silver  
1
  • Ortholog Compara
Ammonium transmembrane transportdefinition[GO:0072488]  
3
  • GOC
  • RefGenome
  • InterPro 2 GO
Dopamine biosynthetic processdefinition[GO:0042416] silver  
1
  • Ortholog Compara
Dopamine catabolic processdefinition[GO:0042420] silver  
1
  • Ortholog Compara
Dopamine transportdefinition[GO:0015872]  
1
  • UniProtKB
Dopamine uptake involved in synaptic transmissiondefinition[GO:0051583]  
1
  • RefGenome
Lactationdefinition[GO:0007595] silver  
1
  • Ortholog Compara
Locomotory behaviordefinition[GO:0007626] silver  
1
  • Ortholog Compara
Monoamine transportdefinition[GO:0015844]  
1
  • MGI
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
1
  • Ortholog Compara
Prepulse inhibitiondefinition[GO:0060134] silver  
1
  • Ortholog Compara
Regulation of dopamine metabolic processdefinition[GO:0042053] silver  
1
  • Ortholog Compara
Response to cocainedefinition[GO:0042220] silver  
1
  • Ortholog Compara
Sensory perception of smelldefinition[GO:0007608] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+6531  
Parkinson's disease  hsa05012+6531  
According to Reactome, this protein belongs to the following pathways:
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)  R-HSA-5660724  
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)  R-HSA-5619081  
Dopamine clearance from the synaptic cleft  R-HSA-379401  
Na+/Cl- dependent neurotransmitter transporters  R-HSA-442660  
Note 
This protein is the target of psychomotor stimulants such as amphetamines or cocaine.  
1
  • UniProtKB
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q01959
Other
GeneWiki: Dopamine_transporter
GenomeRNAi: 6531
PRO: PR:Q01959
Chemistry
GuidetoPHARMACOLOGY: 927