SLC6A3 - Sodium-dependent dopamine transporter - human protein (Function)
 
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Protein
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References

 
SLC6A3 »  Sodium-dependent dopamine transporter  (DAT)
 
Protein also known as:  Solute carrier family 6 member 3.
Gene name:  SLC6A3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter:sodium symporter (nss) family  2.A.22.1.3  
GO molecular function 
Dopamine bindingdefinition[GO:0035240] silver  
  • IEAOrtholog Compara
Dopamine transmembrane transporter activitydefinition[GO:0005329]  
1
  • IDAUniProtKB
Dopamine:sodium symporter activitydefinition[GO:0005330] silver  
  • IEAOrtholog Compara
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Monoamine transmembrane transporter activitydefinition[GO:0008504]  
1
  • IDAMGI
Protease bindingdefinition[GO:0002020] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein N-terminus bindingdefinition[GO:0047485] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
GO biological process 
Adenohypophysis developmentdefinition[GO:0021984] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Dopamine biosynthetic processdefinition[GO:0042416] silver  
  • IEAOrtholog Compara
Dopamine catabolic processdefinition[GO:0042420] silver  
  • IEAOrtholog Compara
Dopamine transportdefinition[GO:0015872]  
1
  • IDAUniProtKB
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Monoamine transportdefinition[GO:0015844]  
1
  • IDAMGI
Neurotransmitter transportdefinition[GO:0006836]  
  • IEAUniProtKB KW
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Prepulse inhibitiondefinition[GO:0060134] silver  
  • IEAOrtholog Compara
Regulation of dopamine metabolic processdefinition[GO:0042053] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Sensory perception of smelldefinition[GO:0007608] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+6531  
Parkinson's disease  hsa05012+6531  
According to Reactome, this protein belongs to the following pathways:
Dopamine clearance from the synaptic cleft  REACT_15514  
Na+/Cl- dependent neurotransmitter transporters  REACT_20506  
Note 
This protein is the target of psychomotor stimulants such as amphetamines or cocaine.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q01959
Other
GeneWiki: Dopamine_transporter
GenomeRNAi: 6531
PRO: PR:Q01959
Chemistry
GuidetoPHARMACOLOGY: 927