GUCY1B3 - Guanylate cyclase soluble subunit beta-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
GUCY1B3 »  Guanylate cyclase soluble subunit beta-1   [ EC 4.6.1.2 ]  (GCS-beta-1)
 
Protein also known as:  Guanylate cyclase soluble subunit beta-3 (GCS-beta-3).
Gene name:  GUCY1B3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 3
GENE REF ISO

Function

 show evidences
GO molecular function 
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB KW
Guanylate cyclase activitydefinition[GO:0004383]  
1
  • EC 2 GO
Heme bindingdefinition[GO:0020037] silver  
1
  • InterPro 2 GO
Hsp90 protein bindingdefinition[GO:0051879] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • PINC
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • PINC
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • UniProtKB KW
Nitric oxide mediated signal transductiondefinition[GO:0007263] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.2: GTP 3',5'-cyclic GMP + diphosphate.  
1
  • UniProtKB
It requires the following cofactor
 heme : Binds 1 or 2 heme groups per heterodimer.  
1
  • UniProtKB
It is regulated in the following manner
Activated by nitric oxide in the presence of magnesium or manganese ions.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+2983  
Long-term depression  hsa04730+2983  
Purine metabolism  hsa00230+2983  
Salivary secretion  hsa04970+2983  
Vascular smooth muscle contraction  hsa04270+2983  
According to Reactome, this protein belongs to the following pathway:
Nitric oxide stimulates guanylate cyclase  REACT_23862  
Note 
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.  
1
  • UniProtKB
 

Keywords

Biological process 
cGMP biosynthesis  definition   [KW-0141]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GUCY1B3
GenomeRNAi: 2983
PRO: PR:Q02153