ALDH6A1 - Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial - human protein (Function)
 
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Protein
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ALDH6A1 »  Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial   [ EC 1.2.1.18EC 1.2.1.27 ]  (MMSDH)
 
Protein also known as:  Aldehyde dehydrogenase family 6 member A1.
Gene name:  ALDH6A1
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 21 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.  
  • CuratedUniProtKB
GO molecular function 
Fatty-acyl-CoA bindingdefinition[GO:0000062]  
  • ISSOrtholog Curator
Malonate-semialdehyde dehydrogenase (acetylating) activitydefinition[GO:0018478]  
  • ISSOrtholog Curator
Methylmalonate-semialdehyde dehydrogenase (acylating) activitydefinition[GO:0004491]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
GO biological process 
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Thymine catabolic processdefinition[GO:0006210]  
1
  • IMPBHF-UCL
Thymine metabolic processdefinition[GO:0019859]  
  • ISSOrtholog Curator
Valine catabolic processdefinition[GO:0006574]  
1
  • IMPBHF-UCL
Valine metabolic processdefinition[GO:0006573]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.2.1.27: 2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) propanoyl-CoA + HCO(3)(-) + NADH.  
  • CuratedUniProtKB
EC 1.2.1.18: 3-oxopropanoate + CoA + NAD(P)(+) acetyl-CoA + CO(2) + NAD(P)H.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+4329  
Inositol phosphate metabolism  hsa00562+4329  
Metabolic pathways  hsa01100+4329  
Propanoate metabolism  hsa00640+4329  
Valine, leucine and isoleucine degradation  hsa00280+4329  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links