BDH1 - D-beta-hydroxybutyrate dehydrogenase, mitochondrial - human protein (Function)
 
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BDH1 »  D-beta-hydroxybutyrate dehydrogenase, mitochondrial   [ EC 1.1.1.30 ]  (BDH)
 
Protein also known as:  3-hydroxybutyrate dehydrogenase.
Gene name:  BDH1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
3-hydroxybutyrate dehydrogenase activitydefinition[GO:0003858]  
1
  • IDAUniProtKB
Phospholipid bindingdefinition[GO:0005543] silver  
  • IEAOrtholog Compara
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Response to cadmium iondefinition[GO:0046686] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to growth hormonedefinition[GO:0060416] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.30: (R)-3-hydroxybutanoate + NAD(+) acetoacetate + NADH.  
  • CuratedUniProtKB
It is regulated in the following manner
Requires phosphatidylcholine as an allosteric activator for enzymatic activity.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+622  
Metabolic pathways  hsa01100+622  
Synthesis and degradation of ketone bodies  hsa00072+622  
According to Reactome, this protein belongs to the following pathways:
Synthesis of Ketone Bodies  REACT_1464  
Utilization of Ketone Bodies  REACT_59  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BDH1
GenomeRNAi: 622
PRO: PR:Q02338