ID2 - DNA-binding protein inhibitor ID-2 - human protein (Function)
 
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ID2 »  DNA-binding protein inhibitor ID-2
 
Protein also known as:  Class B basic helix-loop-helix protein 26 (bHLHb26).
Gene name:  ID2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.  
  • CuratedUniProtKB
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Bundle of His developmentdefinition[GO:0003166] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cellular response to lithium iondefinition[GO:0071285] silver  
  • IEAOrtholog Compara
Cellular senescencedefinition[GO:0090398]  
  • ISSOrtholog Curator
Embryonic digestive tract morphogenesisdefinition[GO:0048557]  
  • ISSOrtholog Curator
Endodermal digestive tract morphogenesisdefinition[GO:0061031]  
  • ISSOrtholog Curator
Entrainment of circadian clockdefinition[GO:0009649] silver  
  • IEAOrtholog Compara
Enucleate erythrocyte differentiationdefinition[GO:0043353] silver  
  • IEAOrtholog Compara
Epithelial cell differentiation involved in mammary gland alveolus developmentdefinition[GO:0061030]  
  • ISSOrtholog Curator
Mammary gland alveolus developmentdefinition[GO:0060749]  
  • ISSOrtholog Curator
Mammary gland epithelial cell proliferationdefinition[GO:0033598]  
  • ISSOrtholog Curator
Membranous septum morphogenesisdefinition[GO:0003149] silver  
  • IEAOrtholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Natural killer cell differentiationdefinition[GO:0001779] silver  
  • IEAOrtholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578] silver  
  • IEAOrtholog Compara
Negative regulation of DNA bindingdefinition[GO:0043392] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
  • ISSOrtholog Curator
Negative regulation of neural precursor cell proliferationdefinition[GO:2000178]  
  • ISSOrtholog Curator
Negative regulation of neuron differentiationdefinition[GO:0045665]  
  • ISSOrtholog Curator
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDAGDB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAGDB
Neuron fate commitmentdefinition[GO:0048663]  
  • ISSOrtholog Curator
Olfactory bulb developmentdefinition[GO:0021772] silver  
  • IEAOrtholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
  • IEAOrtholog Compara
Peyer's patch developmentdefinition[GO:0048541] silver  
  • IEAOrtholog Compara
Positive regulation of astrocyte differentiationdefinition[GO:0048711] silver  
  • IEAOrtholog Compara
Positive regulation of blood pressuredefinition[GO:0045777]  
  • ISSOrtholog Curator
Positive regulation of cell cycledefinition[GO:0045787] silver  
  • IEAOrtholog Compara
Positive regulation of cell cycle arrestdefinition[GO:0071158]  
  • ISSOrtholog Curator
Positive regulation of erythrocyte differentiationdefinition[GO:0045648] silver  
  • IEAOrtholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of macrophage differentiationdefinition[GO:0045651] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
  • ISSOrtholog Curator
Positive regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0071931]  
1
  • ICBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • IMPBHF-UCL
Regulation of lipid metabolic processdefinition[GO:0019216] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+3398  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ID2
GenomeRNAi: 3398
PRO: PR:Q02363