ID2 - DNA-binding protein inhibitor ID-2 - human protein (Function)
 
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Protein
Gene
References

 
ID2 »  DNA-binding protein inhibitor ID-2
 
Protein also known as:  Class B basic helix-loop-helix protein 26 (bHLHb26).
Gene name:  ID2
Entry whose protein(s) existence is based on evidence at protein level
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1 81 1
GENE REF ISO

Function

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Overview 
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.  
  • CuratedUniProtKB
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Bundle of His developmentdefinition[GO:0003166] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cellular response to lithium iondefinition[GO:0071285] silver  
  • IEAOrtholog Compara
Cellular senescencedefinition[GO:0090398]  
  • ISSOrtholog Curator
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Embryonic digestive tract morphogenesisdefinition[GO:0048557]  
  • ISSOrtholog Curator
Endodermal digestive tract morphogenesisdefinition[GO:0061031]  
  • ISSOrtholog Curator
Entrainment of circadian clock by photoperioddefinition[GO:0043153]  
  • ISSOrtholog Curator
Enucleate erythrocyte differentiationdefinition[GO:0043353] silver  
  • IEAOrtholog Compara
Epithelial cell differentiation involved in mammary gland alveolus developmentdefinition[GO:0061030]  
  • ISSOrtholog Curator
Locomotor rhythmdefinition[GO:0045475]  
  • ISSOrtholog Curator
Mammary gland alveolus developmentdefinition[GO:0060749]  
  • ISSOrtholog Curator
Mammary gland epithelial cell proliferationdefinition[GO:0033598]  
  • ISSOrtholog Curator
Membranous septum morphogenesisdefinition[GO:0003149] silver  
  • IEAOrtholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Natural killer cell differentiationdefinition[GO:0001779] silver  
  • IEAOrtholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578] silver  
  • IEAOrtholog Compara
Negative regulation of DNA bindingdefinition[GO:0043392] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
  • ISSOrtholog Curator
Negative regulation of neural precursor cell proliferationdefinition[GO:2000178]  
  • ISSOrtholog Curator
Negative regulation of neuron differentiationdefinition[GO:0045665]  
  • ISSOrtholog Curator
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDAGDB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAGDB
Neuron fate commitmentdefinition[GO:0048663]  
  • ISSOrtholog Curator
Olfactory bulb developmentdefinition[GO:0021772] silver  
  • IEAOrtholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
  • IEAOrtholog Compara
Peyer's patch developmentdefinition[GO:0048541] silver  
  • IEAOrtholog Compara
Positive regulation of astrocyte differentiationdefinition[GO:0048711] silver  
  • IEAOrtholog Compara
Positive regulation of blood pressuredefinition[GO:0045777]  
  • ISSOrtholog Curator
Positive regulation of cell cycledefinition[GO:0045787] silver  
  • IEAOrtholog Compara
Positive regulation of cell cycle arrestdefinition[GO:0071158]  
  • ISSOrtholog Curator
Positive regulation of erythrocyte differentiationdefinition[GO:0045648] silver  
  • IEAOrtholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of macrophage differentiationdefinition[GO:0045651] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
  • ISSOrtholog Curator
Positive regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0071931]  
1
  • ICBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • IMPBHF-UCL
Regulation of lipid metabolic processdefinition[GO:0019216]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+3398  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ID2
GenomeRNAi: 3398
PRO: PR:Q02363