ID2 - DNA-binding protein inhibitor ID-2 - human protein (Function)
 
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Protein
Gene
References

 
ID2 »  DNA-binding protein inhibitor ID-2
 
Protein also known as:  Class B basic helix-loop-helix protein 26 (bHLHb26).
Gene name:  ID2
Entry whose protein(s) existence is based on evidence at protein level
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1 85 1
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.  
2
  • UniProtKB
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
1
  • Ortholog Compara
Bundle of His developmentdefinition[GO:0003166] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to lithium iondefinition[GO:0071285] silver  
1
  • Ortholog Compara
Cellular senescencedefinition[GO:0090398]  
1
  • Ortholog Curator
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Embryonic digestive tract morphogenesisdefinition[GO:0048557]  
1
  • Ortholog Curator
Endodermal digestive tract morphogenesisdefinition[GO:0061031]  
1
  • Ortholog Curator
Entrainment of circadian clock by photoperioddefinition[GO:0043153]  
1
  • Ortholog Curator
Enucleate erythrocyte differentiationdefinition[GO:0043353] silver  
1
  • Ortholog Compara
Epithelial cell differentiation involved in mammary gland alveolus developmentdefinition[GO:0061030]  
1
  • Ortholog Curator
Locomotor rhythmdefinition[GO:0045475]  
1
  • Ortholog Curator
Mammary gland alveolus developmentdefinition[GO:0060749]  
1
  • Ortholog Curator
Mammary gland epithelial cell proliferationdefinition[GO:0033598]  
1
  • Ortholog Curator
Membranous septum morphogenesisdefinition[GO:0003149] silver  
1
  • Ortholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
1
  • Ortholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Natural killer cell differentiationdefinition[GO:0001779] silver  
1
  • Ortholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578] silver  
1
  • Ortholog Compara
Negative regulation of DNA bindingdefinition[GO:0043392] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • Ortholog Curator
Negative regulation of neural precursor cell proliferationdefinition[GO:2000178]  
1
  • Ortholog Curator
Negative regulation of neuron differentiationdefinition[GO:0045665]  
1
  • Ortholog Curator
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
1
  • Ortholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • GDB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • GDB
Neuron fate commitmentdefinition[GO:0048663]  
1
  • Ortholog Curator
Olfactory bulb developmentdefinition[GO:0021772] silver  
1
  • Ortholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
1
  • Ortholog Compara
Peyer's patch developmentdefinition[GO:0048541] silver  
1
  • Ortholog Compara
Positive regulation of astrocyte differentiationdefinition[GO:0048711] silver  
1
  • Ortholog Compara
Positive regulation of blood pressuredefinition[GO:0045777]  
1
  • Ortholog Curator
Positive regulation of cell cycle arrestdefinition[GO:0071158]  
1
  • Ortholog Curator
Positive regulation of erythrocyte differentiationdefinition[GO:0045648] silver  
1
  • Ortholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • Ortholog Curator
Positive regulation of macrophage differentiationdefinition[GO:0045651] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • Ortholog Curator
Positive regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0071931]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Regulation of circadian rhythmdefinition[GO:0042752]  
1
  • Ortholog Curator
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • BHF-UCL
Regulation of lipid metabolic processdefinition[GO:0019216]  
1
  • Ortholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+3398  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ID2
GenomeRNAi: 3398
PRO: PR:Q02363