DSC2 - Desmocollin-2 - human protein (Function)
 
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Protein
Gene
References

 
DSC2 »  Desmocollin-2
 
Protein also known as:  Desmosomal glycoprotein III.
Gene name:  DSC2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 45 2
GENE REF ISO

Function

 show evidences
Overview 
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Bundle of His cell to Purkinje myocyte communicationdefinition[GO:0086069]  
1
  • IMPBHF-UCL
Cardiac muscle cell-cardiac muscle cell adhesiondefinition[GO:0086042]  
1
  • IMPUniProtKB
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Homophilic cell adhesiondefinition[GO:0007156] silver  
  • IEAInterPro 2 GO
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+1824  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DSC2
GenomeRNAi: 1824
PRO: PR:Q02487