ID3 - DNA-binding protein inhibitor ID-3 - human protein (Function)
 
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Protein
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ID3 »  DNA-binding protein inhibitor ID-3
 
Protein also known as:  Class B basic helix-loop-helix protein 25 (bHLHb25).
Gene name:  ID3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.  
1
  • CuratedUniProtKB
GO molecular function 
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
GO biological process 
Central nervous system developmentdefinition[GO:0007417] silver  
  • IEAOrtholog Compara
Epithelial cell differentiationdefinition[GO:0030855] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Muscle organ developmentdefinition[GO:0007517]  
  • IEAUniProtKB KW
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDAGDB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAGDB
Neuron differentiationdefinition[GO:0030182] silver  
  • IEAOrtholog Compara
Notochord developmentdefinition[GO:0030903] silver  
  • IEAOrtholog Compara
Odontogenesisdefinition[GO:0042476] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAOrtholog Compara
Regulation of DNA replicationdefinition[GO:0006275] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+3399  
 

Keywords

Biological process 
Myogenesis  definition   [KW-0517]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ID3_(gene)
GenomeRNAi: 3399
PRO: PR:Q02535