ID3 - DNA-binding protein inhibitor ID-3 - human protein (Function)
 
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Gene
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ID3 »  DNA-binding protein inhibitor ID-3
 
Protein also known as:  Class B basic helix-loop-helix protein 25 (bHLHb25).
Gene name:  ID3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 1
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • Ortholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • PINC
Transcription factor bindingdefinition[GO:0008134] silver  
1
  • Ortholog Compara
GO biological process 
Central nervous system developmentdefinition[GO:0007417] silver  
1
  • Ortholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Epithelial cell differentiationdefinition[GO:0030855] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
1
  • Ortholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Muscle organ developmentdefinition[GO:0007517]  
1
  • UniProtKB KW
Negative regulation of myoblast differentiationdefinition[GO:0045662] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
1
  • Ortholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • GDB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • GDB
Neuron differentiationdefinition[GO:0030182] silver  
1
  • Ortholog Compara
Notochord developmentdefinition[GO:0030903] silver  
1
  • Ortholog Compara
Odontogenesisdefinition[GO:0042476] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Regulation of cell cycledefinition[GO:0051726] silver  
1
  • Ortholog Compara
Regulation of DNA replicationdefinition[GO:0006275] silver  
1
  • Ortholog Compara
Response to woundingdefinition[GO:0009611] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+3399  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Myogenesis  definition   [KW-0517]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ID3_(gene)
GenomeRNAi: 3399
PRO: PR:Q02535