PAX5 - Paired box protein Pax-5 - human protein (Function)
 
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PAX5 »  Paired box protein Pax-5
 
Protein also known as:  B-cell-specific transcription factor (BSAP).
Gene name:  PAX5
Entry whose protein(s) existence is based on evidence at protein level
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1 103 11
GENE REF ISO

Function

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Overview 
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Humoral immune responsedefinition[GO:0006959]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of histone H3-K9 methylationdefinition[GO:0051573] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
  • IEAUniProtKB KW
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283]  
  • IEAUniProtKB KW
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Spermatogenesis  definition   [KW-0744]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PAX5
GenomeRNAi: 5079
PRO: PR:Q02548