IRF8 - Interferon regulatory factor 8 - human protein (Function)
 
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IRF8 »  Interferon regulatory factor 8  (IRF-8)
 
Protein also known as:  Interferon consensus sequence-binding protein (ICSBP).
Gene name:  IRF8
Family name: IRF
Entry whose protein(s) existence is based on evidence at protein level
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1 73 1
GENE REF ISO

Function

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Overview 
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Regulatory region DNA bindingdefinition[GO:0000975] silver  
  • IEAInterPro 2 GO
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • TASPINC
GO biological process 
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Defense response to bacteriumdefinition[GO:0042742] silver  
  • IEAOrtholog Compara
Defense response to protozoandefinition[GO:0042832] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Myeloid cell differentiationdefinition[GO:0030099] silver  
  • IEAOrtholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • TASPINC
Phagocytosisdefinition[GO:0006909] silver  
  • IEAOrtholog Compara
Positive regulation of interferon-gamma productiondefinition[GO:0032729] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-12 productiondefinition[GO:0032735] silver  
  • IEAOrtholog Compara
Positive regulation of transcription initiation from RNA polymerase II promoterdefinition[GO:0060261] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pertussis  hsa05133+3394  
According to Reactome, this protein belongs to the following pathways:
Interferon alpha/beta signaling  REACT_25162  
Interferon gamma signaling  REACT_25078  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRF8
GenomeRNAi: 3394
PRO: PR:Q02556