CACNB1 - Voltage-dependent L-type calcium channel subunit beta-1 - human protein (Function)
 
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CACNB1 »  Voltage-dependent L-type calcium channel subunit beta-1  (CAB1)
 
Protein also known as:  Calcium channel voltage-dependent subunit beta 1.
Gene name:  CACNB1
Entry whose protein(s) existence is based on evidence at protein level
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1 22 3
GENE REF ISO

Function

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Overview 
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.  
  • CuratedUniProtKB
GO molecular function 
High voltage-gated calcium channel activitydefinition[GO:0008331] silver  
  • IEAOrtholog Compara
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • TASPINC
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Protein targeting to membranedefinition[GO:0006612] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+782  
Cardiac muscle contraction  hsa04260+782  
Dilated cardiomyopathy  hsa05414+782  
Hypertrophic cardiomyopathy (HCM)  hsa05410+782  
MAPK signaling pathway  hsa04010+782  
According to Reactome, this protein belongs to the following pathways:
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels  REACT_13606  
NCAM1 interactions  REACT_18312  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNB1
GenomeRNAi: 782
PRO: PR:Q02641