GHRHR - Growth hormone-releasing hormone receptor - human protein (Function)
 
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GHRHR »  Growth hormone-releasing hormone receptor  (GHRH receptor)
 
Protein also known as:  Growth hormone-releasing factor receptor (GRFR).
Gene name:  GHRHR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.7  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • ICBHF-UCL
Growth factor bindingdefinition[GO:0019838]  
1
  • IPIBHF-UCL
Growth hormone-releasing hormone receptor activitydefinition[GO:0016520]  
1
  • IMPBHF-UCL
Peptide hormone bindingdefinition[GO:0017046]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIBHF-UCL
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190] silver  
  • IEAOrtholog Compara
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • IDABHF-UCL
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • IMPBHF-UCL
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cellular response to insulin stimulusdefinition[GO:0032869] silver  
  • IEAOrtholog Compara
Determination of adult lifespandefinition[GO:0008340] silver  
  • IEAOrtholog Compara
Growth hormone secretiondefinition[GO:0030252] silver  
  • IEAOrtholog Compara
Hormone metabolic processdefinition[GO:0042445] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Multicellular organismal reproductive processdefinition[GO:0048609]  
1
  • NASBHF-UCL
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of growth hormone secretiondefinition[GO:0060124]  
1
  • NASBHF-UCL
Positive regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043568]  
1
  • NASBHF-UCL
Positive regulation of multicellular organism growthdefinition[GO:0040018]  
1
  • IMPBHF-UCL
Regulation of intracellular steroid hormone receptor signaling pathwaydefinition[GO:0033143] silver  
  • IEAOrtholog Compara
Regulation of protein metabolic processdefinition[GO:0051246] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627]  
1
  • IDABHF-UCL
Response to glucocorticoiddefinition[GO:0051384]  
1
  • IDABHF-UCL
Response to insulindefinition[GO:0032868]  
1
  • IMPBHF-UCL
Somatotropin secreting cell developmentdefinition[GO:0060133] silver  
  • IEAOrtholog Compara
Water homeostasisdefinition[GO:0030104] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2692  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Glucagon-type ligand receptors  REACT_18377  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Growth-hormone-releasing_hormone_receptor
GeneWiki: Growth_hormone-releasing_hormone_receptor
GenomeRNAi: 2692
PRO: PR:Q02643
Chemistry
GuidetoPHARMACOLOGY: 247