MAP3K10 - Mitogen-activated protein kinase kinase kinase 10 - human protein (Function)
 
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MAP3K10 »  Mitogen-activated protein kinase kinase kinase 10   [ EC 2.7.11.25 ]
 
Protein also known as:  Mixed lineage kinase 2.
Gene name:  MAP3K10
Entry whose protein(s) existence is based on evidence at protein level
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1 33 1
GENE REF ISO

Function

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Overview 
Activates the JUN N-terminal pathway (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
bHLH transcription factor bindingdefinition[GO:0043425]  
1
  • IPIUniProtKB
JUN kinase kinase kinase activitydefinition[GO:0004706]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • ISSUniProtKB
Protein kinase activitydefinition[GO:0004672]  
2
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
  • ISSOrtholog Curator
GO biological process 
Activation of JNKK activitydefinition[GO:0007256]  
  • ISSOrtholog Curator
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • ISSUniProtKB
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
JNK cascadedefinition[GO:0007254]  
1
  • TASPINC
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IMPUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDAUniProtKB
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • IMPUniProtKB
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • ISSUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Smoothened signaling pathwaydefinition[GO:0007224]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K10
GenomeRNAi: 4294
PRO: PR:Q02779
Chemistry
GuidetoPHARMACOLOGY: 2070