FKBP4 - Peptidyl-prolyl cis-trans isomerase FKBP4 - human protein (Function)
 
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FKBP4 »  Peptidyl-prolyl cis-trans isomerase FKBP4   [ EC 5.2.1.8 ]  (PPIase FKBP4)
 
Protein also known as:  51 kDa FK506-binding protein (FKBP51). Cleaved into:  Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed.
Gene name:  FKBP4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 83 1
GENE REF ISO

Function

 show evidences
Overview 
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.  
6
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
1
  • Ortholog Compara
Copper-dependent protein bindingdefinition[GO:0032767] silver  
1
  • Ortholog Compara
FK506 bindingdefinition[GO:0005528]  
2
  • UniProtKB
  • RefGenome
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
1
  • Ortholog Compara
GTP bindingdefinition[GO:0005525] silver  
1
  • Ortholog Compara
Heat shock protein bindingdefinition[GO:0031072]  
1
  • UniProtKB
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
1
  • UniProtKB
Phosphoprotein bindingdefinition[GO:0051219] silver  
1
  • Ortholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • PINC
Tau protein bindingdefinition[GO:0048156] silver  
1
  • Ortholog Compara
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521] silver  
1
  • Ortholog Compara
Chaperone-mediated protein foldingdefinition[GO:0061077]  
1
  • UniProtKB
Copper ion transportdefinition[GO:0006825] silver  
1
  • Ortholog Compara
Embryo implantationdefinition[GO:0007566] silver  
1
  • Ortholog Compara
Male sex differentiationdefinition[GO:0046661] silver  
1
  • Ortholog Compara
Negative regulation of microtubule polymerizationdefinition[GO:0031115] silver  
1
  • Ortholog Compara
Negative regulation of microtubule polymerization or depolymerizationdefinition[GO:0031111]  
1
  • Ortholog Curator
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
1
  • Ortholog Curator
Prostate gland developmentdefinition[GO:0030850] silver  
1
  • Ortholog Compara
Protein complex localizationdefinition[GO:0031503] silver  
1
  • Ortholog Compara
Protein foldingdefinition[GO:0006457]  
1
  • PINC
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
3
  • GOC
  • EC 2 GO
  • UniProtKB KW
Steroid hormone receptor complex assemblydefinition[GO:0006463] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by FK506.  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Attenuation phase  REACT_264075  
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP52
GenomeRNAi: 2288
PRO: PR:Q02790