FKBP4 - Peptidyl-prolyl cis-trans isomerase FKBP4 - human protein (Function)
 
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FKBP4 »  Peptidyl-prolyl cis-trans isomerase FKBP4   [ EC 5.2.1.8 ]  (PPIase FKBP4)
 
Protein also known as:  51 kDa FK506-binding protein (FKBP51). Cleaved into:  Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed.
Gene name:  FKBP4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 75 1
GENE REF ISO

Function

 show evidences
Overview 
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Copper-dependent protein bindingdefinition[GO:0032767] silver  
  • IEAOrtholog Compara
FK506 bindingdefinition[GO:0005528]  
1
  • TASUniProtKB
  • IBARefGenome
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
  • IEAOrtholog Compara
GTP bindingdefinition[GO:0005525] silver  
  • IEAOrtholog Compara
Heat shock protein bindingdefinition[GO:0031072]  
1
  • IPIUniProtKB
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
1
  • IDAUniProtKB
Phosphoprotein bindingdefinition[GO:0051219] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • TASPINC
Tau protein bindingdefinition[GO:0048156] silver  
  • IEAOrtholog Compara
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521] silver  
  • IEAOrtholog Compara
Chaperone-mediated protein foldingdefinition[GO:0061077]  
1
  • IDAUniProtKB
Copper ion transportdefinition[GO:0006825] silver  
  • IEAOrtholog Compara
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Male sex differentiationdefinition[GO:0046661] silver  
  • IEAOrtholog Compara
Negative regulation of microtubule polymerizationdefinition[GO:0031115] silver  
  • IEAOrtholog Compara
Negative regulation of microtubule polymerization or depolymerizationdefinition[GO:0031111]  
  • ISSOrtholog Curator
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
  • ISSOrtholog Curator
Prostate gland developmentdefinition[GO:0030850] silver  
  • IEAOrtholog Compara
Protein complex localizationdefinition[GO:0031503] silver  
  • IEAOrtholog Compara
Protein foldingdefinition[GO:0006457]  
1
  • TASPINC
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
1
  • IDAGOC
Steroid hormone receptor complex assemblydefinition[GO:0006463] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by FK506.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cellular responses to stress  REACT_120956  
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP52
GenomeRNAi: 2288
PRO: PR:Q02790