TOP2B - DNA topoisomerase 2-beta - human protein (Function)
 
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TOP2B »  DNA topoisomerase 2-beta   [ EC 5.99.1.3 ]
 
Protein also known as:  DNA topoisomerase II, beta isozyme.
Gene name:  TOP2B
Family name: Type II topoisomerase
Entry whose protein(s) existence is based on evidence at protein level
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1 94 2
GENE REF ISO

Function

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Overview 
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Chromatin bindingdefinition[GO:0003682]  
1
  • UniProtKB
DNA binding, bendingdefinition[GO:0008301] silver  
1
  • InterPro 2 GO
DNA topoisomerase type II (ATP-hydrolyzing) activitydefinition[GO:0003918]  
1
  • UniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Histone deacetylase bindingdefinition[GO:0042826]  
2
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • UniProtKB
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
1
  • Ortholog Compara
DNA topological changedefinition[GO:0006265]  
1
  • UniProtKB
DNA unwinding involved in DNA replicationdefinition[GO:0006268]  
1
  • RefGenome
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Mitotic DNA integrity checkpointdefinition[GO:0044774]  
1
  • RefGenome
Mitotic recombinationdefinition[GO:0006312]  
1
  • RefGenome
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Resolution of meiotic recombination intermediatesdefinition[GO:0000712]  
1
  • RefGenome
Sister chromatid segregationdefinition[GO:0000819]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.99.1.3: ATP-dependent breakage, passage and rejoining of double-stranded DNA.  
3
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Mg(2+) : Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).  
4
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Note 
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.  
1
  • UniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Topoisomerase  definition   [KW-0799]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TOP2B
GenomeRNAi: 7155
PRO: PR:Q02880