TOP2B - DNA topoisomerase 2-beta - human protein (Function)
 
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TOP2B »  DNA topoisomerase 2-beta   [ EC 5.99.1.3 ]
 
Protein also known as:  DNA topoisomerase II, beta isozyme.
Gene name:  TOP2B
Family name: Type II topoisomerase
Entry whose protein(s) existence is based on evidence at protein level
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1 72 2
GENE REF ISO

Function

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Overview 
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
DNA topoisomerase type II (ATP-hydrolyzing) activitydefinition[GO:0003918]  
1
  • IDAUniProtKB
  • IBARefGenome
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Histone deacetylase bindingdefinition[GO:0042826]  
2
  • IPIUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • IPIUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
  • IBARefGenome
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Chromosome segregationdefinition[GO:0007059] silver  
  • IBARefGenome
DNA topological changedefinition[GO:0006265]  
1
  • IDAUniProtKB
  • IBARefGenome
DNA-dependent DNA replicationdefinition[GO:0006261] silver  
  • IBARefGenome
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Mitotic recombinationdefinition[GO:0006312] silver  
  • IBARefGenome
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Resolution of meiotic recombination intermediatesdefinition[GO:0000712] silver  
  • IBARefGenome
Sister chromatid segregationdefinition[GO:0000819] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.99.1.3: ATP-dependent breakage, passage and rejoining of double-stranded DNA.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium. Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) and Ca(2+).  
2
  • CuratedUniProtKB
Note 
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Topoisomerase  definition   [KW-0799]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TOP2B
GenomeRNAi: 7155
PRO: PR:Q02880