CREM - cAMP-responsive element modulator - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CREM »  cAMP-responsive element modulator
 
Protein also known as:  Inducible cAMP early repressor (ICER).
Gene name:  CREM
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 66 29
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
cAMP response element binding protein bindingdefinition[GO:0008140]  
1
  • NASUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Isoform  Iso 9   Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Glycosphingolipid metabolic processdefinition[GO:0006687] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Spermatogenesisdefinition[GO:0007283]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links