CREM - cAMP-responsive element modulator - human protein (Function)
 
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CREM »  cAMP-responsive element modulator
 
Protein also known as:  Inducible cAMP early repressor (ICER).
Gene name:  CREM
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed10373550).  
2
  • UniProtKB
GO molecular function 
cAMP response element binding protein bindingdefinition[GO:0008140]  
1
  • UniProtKB
Core promoter sequence-specific DNA bindingdefinition[GO:0001046] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • InterPro 2 GO
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Circadian regulation of gene expressiondefinition[GO:0032922] silver  
1
  • Ortholog Compara
Glycosphingolipid metabolic processdefinition[GO:0006687] silver  
1
  • Ortholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • UniProtKB
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Spermatogenesisdefinition[GO:0007283]  
1
  • UniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links