CAV1 - Caveolin-1 - human protein (Function)
 
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Protein
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CAV1 »  Caveolin-1
 
Gene name:  CAV1
Family name: Caveolin
Entry whose protein(s) existence is based on evidence at protein level
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1 481 2
GENE REF ISO

Function

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Overview 
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the caveolin (caveolin) family  8.A.26.1.1  
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
1
  • TASHGNC
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Nitric-oxide synthase bindingdefinition[GO:0050998]  
1
  • IPIBHF-UCL
Patched bindingdefinition[GO:0005113]  
1
  • NASBHF-UCL
Peptidase activator activitydefinition[GO:0016504]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIHGNC
Protein complex scaffolddefinition[GO:0032947]  
1
  • TASBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Structural molecule activitydefinition[GO:0005198]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IMPUniProtKB
Calcium ion homeostasisdefinition[GO:0055074]  
  • ISSOrtholog Curator
Calcium ion transportdefinition[GO:0006816]  
  • ISSOrtholog Curator
Caveola assemblydefinition[GO:0070836]  
1
  • IMPBHF-UCL
Caveolin-mediated endocytosisdefinition[GO:0072584]  
1
  • IDAUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
  • ISSOrtholog Curator
Cellular response to hyperoxiadefinition[GO:0071455]  
1
  • IMPUniProtKB
Isoform  Beta   Cellular response to starvationdefinition[GO:0009267]  
1
  • IEPBHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • TASHGNC
  • ISSOrtholog Curator
Cholesterol transportdefinition[GO:0030301]  
1
  • TASHGNC
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
1
  • IDABHF-UCL
Inactivation of MAPK activitydefinition[GO:0000188]  
  • ISSOrtholog Curator
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Lipid storagedefinition[GO:0019915]  
  • ISSOrtholog Curator
Maintenance of protein location in celldefinition[GO:0032507]  
  • ISSOrtholog Curator
Mammary gland developmentdefinition[GO:0030879]  
  • ISSOrtholog Curator
Mammary gland involutiondefinition[GO:0060056]  
  • ISSOrtholog Curator
MAPK cascadedefinition[GO:0000165] silver  
  • IEAOrtholog Compara
Membrane depolarizationdefinition[GO:0051899]  
  • ISSOrtholog Curator
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • IMPUniProtKB
Isoform  Beta   Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
1
  • IDABHF-UCL
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
  • ISSOrtholog Curator
Negative regulation of cytokine-mediated signaling pathwaydefinition[GO:0001960] silver  
  • IEAOrtholog Compara
Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
  • ISSOrtholog Curator
Negative regulation of epithelial cell differentiationdefinition[GO:0030857]  
  • ISSOrtholog Curator
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
  • ISSOrtholog Curator
Negative regulation of MAPK cascadedefinition[GO:0043409]  
  • ISSOrtholog Curator
Negative regulation of nitric oxide biosynthetic processdefinition[GO:0045019]  
  • ISSOrtholog Curator
Negative regulation of nitric-oxide synthase activitydefinition[GO:0051001] silver  
  • IEAOrtholog Compara
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137]  
1
  • IDABHF-UCL
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • IDABHF-UCL
Negative regulation of protein ubiquitinationdefinition[GO:0031397]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Negative regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042524] silver  
  • IEAOrtholog Compara
Nitric oxide homeostasisdefinition[GO:0033484]  
  • ISSOrtholog Curator
Positive regulation of calcium ion transport into cytosoldefinition[GO:0010524]  
1
  • ISSBHF-UCL
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IMPBHF-UCL
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IMPUniProtKB
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244]  
1
  • IMPUniProtKB
Positive regulation of metalloenzyme activitydefinition[GO:0048554]  
  • ISSOrtholog Curator
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDABHF-UCL
Positive regulation of vasoconstrictiondefinition[GO:0045907]  
  • ISSOrtholog Curator
Protein homooligomerizationdefinition[GO:0051260]  
  • ISSOrtholog Curator
Protein localizationdefinition[GO:0008104]  
  • ISSOrtholog Curator
Receptor internalization involved in canonical Wnt signaling pathwaydefinition[GO:2000286]  
1
  • IMPBHF-UCL
Regulation of blood coagulationdefinition[GO:0030193]  
1
  • IMPBHF-UCL
Regulation of fatty acid metabolic processdefinition[GO:0019217]  
  • ISSOrtholog Curator
Regulation of peptidase activitydefinition[GO:0052547]  
  • ISSOrtholog Curator
Regulation of smooth muscle contractiondefinition[GO:0006940]  
  • ISSOrtholog Curator
Regulation of the force of heart contraction by chemical signaldefinition[GO:0003057] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592]  
1
  • ISSBHF-UCL
Response to estrogendefinition[GO:0043627]  
1
  • IDAMGI
Response to hypoxiadefinition[GO:0001666]  
  • ISSOrtholog Curator
Response to ischemiadefinition[GO:0002931] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570]  
1
  • IDAMGI
Skeletal muscle tissue developmentdefinition[GO:0007519]  
  • ISSOrtholog Curator
T cell costimulationdefinition[GO:0031295]  
1
  • IDAUniProtKB
Triglyceride metabolic processdefinition[GO:0006641]  
  • ISSOrtholog Curator
Vasculogenesisdefinition[GO:0001570]  
  • ISSOrtholog Curator
Vasoconstrictiondefinition[GO:0042310] silver  
  • IEAOrtholog Compara
Vesicle organizationdefinition[GO:0016050]  
1
  • IDABHF-UCL
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+857  
Endocytosis  hsa04144+857  
Focal adhesion  hsa04510+857  
Viral myocarditis  hsa05416+857  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Caveolin_1
GenomeRNAi: 857
PRO: PR:Q03135