ACY1 - Aminoacylase-1 - human protein (Function)
 
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ACY1 »  Aminoacylase-1   [ EC 3.5.1.14 ]  (ACY-1)
 
Protein also known as:  N-acyl-L-amino-acid amidohydrolase.
Gene name:  ACY1
Family name: Peptidase M20A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).  
1
  • CuratedUniProtKB
GO molecular function 
Aminoacylase activitydefinition[GO:0004046]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metallopeptidase activitydefinition[GO:0008237] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
An N-acyl-aliphatic-L-amino acid + H(2)O an aliphatic L-amino acid + a carboxylate.  
1
  • CuratedUniProtKB
An N-acetyl-L-cysteine-S-conjugate + H(2)O an L-cysteine-S-conjugate + acetate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+95  
Metabolic pathways  hsa01100+95  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q03154
Other
GeneWiki: ACY1
GenomeRNAi: 95
PRO: PR:Q03154