TGFBR3 - Transforming growth factor beta receptor type 3 - human protein (Function)
 
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TGFBR3 »  Transforming growth factor beta receptor type 3  (TGFR-3)
 
Protein also known as:  Transforming growth factor beta receptor III (TGF-beta receptor type III).
Gene name:  TGFBR3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.  
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185] silver  
  • IEAOrtholog Compara
Coreceptor activitydefinition[GO:0015026]  
1
  • IDABHF-UCL
Fibroblast growth factor bindingdefinition[GO:0017134] silver  
  • IEAOrtholog Compara
Glycosaminoglycan bindingdefinition[GO:0005539]  
1
  • TASBHF-UCL
  • ISSOrtholog Curator
Heparin bindingdefinition[GO:0008201]  
1
  • ISSBHF-UCL
PDZ domain bindingdefinition[GO:0030165]  
  • ISSOrtholog Curator
Contributes to protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIBHF-UCL
SMAD bindingdefinition[GO:0046332]  
1
  • IMPBHF-UCL
Transforming growth factor beta bindingdefinition[GO:0050431]  
2
  • IDABHF-UCL
Transforming growth factor beta receptor activity, type IIIdefinition[GO:0070123]  
2
  • IDABHF-UCL
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • ISSBHF-UCL
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024]  
1
  • IDABHF-UCL
Type II transforming growth factor beta receptor bindingdefinition[GO:0005114]  
1
  • IDABHF-UCL
GO biological process 
Blastocyst developmentdefinition[GO:0001824] silver  
  • IEAOrtholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IDABHF-UCL
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317]  
1
  • IDABHF-UCL
Cardiac muscle cell proliferationdefinition[GO:0060038]  
  • ISSOrtholog Curator
Cell growthdefinition[GO:0016049]  
1
  • ISSBHF-UCL
Cell migrationdefinition[GO:0016477]  
  • ISSOrtholog Curator
Definitive erythrocyte differentiationdefinition[GO:0060318]  
  • ISSOrtholog Curator
Definitive hemopoiesisdefinition[GO:0060216]  
  • ISSOrtholog Curator
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • IDABHF-UCL
Heart morphogenesisdefinition[GO:0003007]  
  • ISSOrtholog Curator
Heart trabecula formationdefinition[GO:0060347]  
  • ISSOrtholog Curator
Immune responsedefinition[GO:0006955]  
1
  • IMPBHF-UCL
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IMPBHF-UCL
Liver developmentdefinition[GO:0001889]  
  • ISSOrtholog Curator
Negative regulation of cellular component movementdefinition[GO:0051271]  
1
  • IDABHF-UCL
Negative regulation of epithelial cell migrationdefinition[GO:0010633] silver  
  • IEAOrtholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
  • ISSOrtholog Curator
Negative regulation of epithelial to mesenchymal transitiondefinition[GO:0010719] silver  
  • IEAOrtholog Compara
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
1
  • IMPBHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
  • IEAOrtholog Compara
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511] silver  
  • IEAOrtholog Compara
Regulation of protein bindingdefinition[GO:0043393] silver  
  • IEAOrtholog Compara
Response to follicle-stimulating hormonedefinition[GO:0032354]  
1
  • IDABHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to luteinizing hormonedefinition[GO:0034699]  
1
  • IDABHF-UCL
Response to prostaglandin Edefinition[GO:0034695]  
1
  • IDABHF-UCL
Transforming growth factor beta receptor complex assemblydefinition[GO:0007181] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
2
  • IDABHF-UCL
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
  • ISSOrtholog Curator
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TGFBR3
GenomeRNAi: 7049
PRO: PR:Q03167