PPARD - Peroxisome proliferator-activated receptor delta - human protein (Function)
 
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PPARD »  Peroxisome proliferator-activated receptor delta  (PPAR-delta)
 
Protein also known as:  Peroxisome proliferator-activated receptor beta (PPAR-beta).
Gene name:  PPARD
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 228 4
GENE REF ISO

Function

 show evidences
Overview 
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.  
3
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • Ortholog Curator
Drug bindingdefinition[GO:0008144]  
2
  • UniProtKB
  • BHF-UCL
Linoleic acid bindingdefinition[GO:0070539]  
1
  • UniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingdefinition[GO:0004879]  
1
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
2
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915] silver  
1
  • CACAO
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • UniProtKB
Axon ensheathmentdefinition[GO:0008366]  
1
  • Ortholog Curator
Cell differentiationdefinition[GO:0030154] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283]  
2
  • UniProtKB
  • Ortholog Curator
Cell-substrate adhesiondefinition[GO:0031589] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • UniProtKB
Decidualizationdefinition[GO:0046697]  
1
  • UniProtKB
Embryo implantationdefinition[GO:0007566]  
1
  • UniProtKB
Fatty acid beta-oxidationdefinition[GO:0006635]  
3
  • UniProtKB
  • Ortholog Curator
Fatty acid catabolic processdefinition[GO:0009062]  
1
  • UniProtKB
Fatty acid transportdefinition[GO:0015908]  
1
  • Ortholog Curator
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • PINC
Glucose metabolic processdefinition[GO:0006006]  
1
  • UniProtKB
Glucose transportdefinition[GO:0015758]  
1
  • UniProtKB
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
2
  • GOC
  • InterPro 2 GO
Keratinocyte migrationdefinition[GO:0051546] silver  
1
  • Ortholog Compara
Keratinocyte proliferationdefinition[GO:0043616] silver  
1
  • Ortholog Compara
Lipid metabolic processdefinition[GO:0006629]  
1
  • Ortholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Negative regulation of myoblast differentiationdefinition[GO:0045662] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • Ortholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • Ortholog Curator
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • UniProtKB
Positive regulation of myoblast proliferationdefinition[GO:2000288] silver  
1
  • Ortholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
1
  • Ortholog Compara
Positive regulation of skeletal muscle tissue regenerationdefinition[GO:0043415] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of satellite cell proliferationdefinition[GO:0014842] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+5467  
Pathways in cancer  hsa05200+5467  
PPAR signaling pathway  hsa03320+5467  
Wnt signaling pathway  hsa04310+5467  
According to Reactome, this protein belongs to the following pathways:
Import of palmitoyl-CoA into the mitochondrial matrix  R-HSA-200425  
Nuclear Receptor transcription pathway  R-HSA-383280  
Regulation of pyruvate dehydrogenase (PDH) complex  R-HSA-204174  
Signaling by Retinoic Acid  R-HSA-5362517  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Peroxisome_proliferator-activated_receptor_delta
GenomeRNAi: 5467
PRO: PR:Q03181
Chemistry
GuidetoPHARMACOLOGY: 594