PPARD - Peroxisome proliferator-activated receptor delta - human protein (Function)
 
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PPARD »  Peroxisome proliferator-activated receptor delta  (PPAR-delta)
 
Protein also known as:  Peroxisome proliferator-activated receptor beta (PPAR-beta).
Gene name:  PPARD
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 206 4
GENE REF ISO

Function

 show evidences
Overview 
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Drug bindingdefinition[GO:0008144]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDAUniProtKB
Linoleic acid bindingdefinition[GO:0070539]  
1
  • IDAUniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • IDAUniProtKB
NF-kappaB bindingdefinition[GO:0051059] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Anagendefinition[GO:0042640] silver  
  • IEAOrtholog Compara
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IMPUniProtKB
Axon ensheathmentdefinition[GO:0008366]  
  • ISSOrtholog Curator
Cell differentiationdefinition[GO:0030154] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Cell-substrate adhesiondefinition[GO:0031589] silver  
  • IEAOrtholog Compara
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • TASUniProtKB
Decidualizationdefinition[GO:0046697]  
1
  • TASUniProtKB
Embryo implantationdefinition[GO:0007566]  
1
  • TASUniProtKB
Fatty acid beta-oxidationdefinition[GO:0006635]  
2
  • TASUniProtKB
  • ISSOrtholog Curator
Fatty acid catabolic processdefinition[GO:0009062]  
1
  • TASUniProtKB
Fatty acid transportdefinition[GO:0015908]  
  • ISSOrtholog Curator
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Glucose metabolic processdefinition[GO:0006006]  
1
  • NASUniProtKB
Glucose transportdefinition[GO:0015758]  
1
  • NASUniProtKB
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • IDAGOC
  • IEAInterPro 2 GO
Keratinocyte migrationdefinition[GO:0051546] silver  
  • IEAOrtholog Compara
Keratinocyte proliferationdefinition[GO:0043616] silver  
  • IEAOrtholog Compara
Lipid metabolic processdefinition[GO:0006629]  
  • ISSOrtholog Curator
mRNA transcriptiondefinition[GO:0009299] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of collagen biosynthetic processdefinition[GO:0032966] silver  
  • IEAOrtholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912] silver  
  • IEAOrtholog Compara
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Phospholipid biosynthetic processdefinition[GO:0008654] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of epidermis developmentdefinition[GO:0045684] silver  
  • IEAOrtholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • NASUniProtKB
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Positive regulation of vasodilationdefinition[GO:0045909] silver  
  • IEAOrtholog Compara
Proteoglycan metabolic processdefinition[GO:0006029] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
  • IEAInterPro 2 GO
Vitamin A metabolic processdefinition[GO:0006776] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+5467  
Pathways in cancer  hsa05200+5467  
PPAR signaling pathway  hsa03320+5467  
Wnt signaling pathway  hsa04310+5467  
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  REACT_15525  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Peroxisome_proliferator-activated_receptor_delta
GenomeRNAi: 5467
PRO: PR:Q03181
Chemistry
GuidetoPHARMACOLOGY: 594