PTS - 6-pyruvoyl tetrahydrobiopterin synthase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PTS »  6-pyruvoyl tetrahydrobiopterin synthase   [ EC 4.2.3.12 ]  (PTPS)
 
Gene name:  PTS
Family name: PTPS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • TASPINC
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
Tetrahydrobiopterin biosynthetic processdefinition[GO:0006729]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.3.12: 7,8-dihydroneopterin 3'-triphosphate 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Folate biosynthesis  hsa00790+5805  
Metabolic pathways  hsa01100+5805  
According to Reactome, this protein belongs to the following pathway:
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation  REACT_111176  
 
More information is available from:
Note 
The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 8.1 uM for 7,8-dihydroneopterin triphosphate
Vmax 120 nmol/min/mg enzyme

Keywords

Biological process 
Tetrahydrobiopterin biosynthesis  definition   [KW-0783]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q03393
Other
GeneWiki: PTS_(gene)
GenomeRNAi: 5805
PRO: PR:Q03393