PTH1R - Parathyroid hormone/parathyroid hormone-related peptide receptor - human protein (Function)
 
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PTH1R »  Parathyroid hormone/parathyroid hormone-related peptide receptor
 
Protein also known as:  Parathyroid hormone 1 receptor (PTH1 receptor).
Gene name:  PTH1R
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.11  
GO molecular function 
Parathyroid hormone receptor activitydefinition[GO:0004991]  
1
  • IDAUniProtKB
Peptide hormone bindingdefinition[GO:0017046]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein self-associationdefinition[GO:0043621]  
1
  • IDAUniProtKB
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
  • ISSOrtholog Curator
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • IDAUniProtKB
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Chondrocyte differentiationdefinition[GO:0002062] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Osteoblast developmentdefinition[GO:0002076] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • ICBHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of inositol phosphate biosynthetic processdefinition[GO:0060732]  
  • ISSOrtholog Curator
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocrine and other factor-regulated calcium reabsorption  hsa04961+5745  
Neuroactive ligand-receptor interaction  hsa04080+5745  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Parathyroid_hormone_1_receptor
GenomeRNAi: 5745
PRO: PR:Q03431
Chemistry
GuidetoPHARMACOLOGY: 331