TAP2 - Antigen peptide transporter 2 - human protein (Function)
 
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TAP2 »  Antigen peptide transporter 2
 
Gene name:  TAP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.209.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
MHC class Ib protein bindingdefinition[GO:0023029]  
1
  • IPIUniProtKB
Peptide antigen-transporting ATPase activitydefinition[GO:0015433]  
1
  • IMPUniProtKB
Contributes to peptide transporter activitydefinition[GO:0015197]  
1
  • IGIUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
TAP1 bindingdefinition[GO:0046978]  
2
  • IPIUniProtKB
Tapasin bindingdefinition[GO:0046980]  
  • ISSOrtholog Curator
Transporter activitydefinition[GO:0005215]  
1
  • IDAMGI
GO biological process 
Antigen processing and presentation of endogenous peptide antigen via MHC class Idefinition[GO:0019885]  
2
  • IDAUniProtKB
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependentdefinition[GO:0002485] silver  
  • IBARefGenome
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependentdefinition[GO:0002489]  
1
  • IMPUniProtKB
Antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependentdefinition[GO:0002481] silver  
  • IBARefGenome
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Cytosol to ER transportdefinition[GO:0046967]  
1
  • IMPUniProtKB
Intracellular transport of viral protein in host celldefinition[GO:0019060]  
1
  • IMPUniProtKB
Peptide antigen transportdefinition[GO:0046968]  
2
  • IDAUniProtKB
Positive regulation of antigen processing and presentation of peptide antigen via MHC class Idefinition[GO:0002591] silver  
  • IBARefGenome
Transmembrane transportdefinition[GO:0055085] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+6891  
Antigen processing and presentation  hsa04612+6891  
Herpes simplex infection  hsa05168+6891  
Phagosome  hsa04145+6891  
Primary immunodeficiency  hsa05340+6891  
According to Reactome, this protein belongs to the following pathways:
Antigen Presentation: Folding, assembly and peptide loading of class I MHC  REACT_75795  
ER-Phagosome pathway  REACT_111178  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Peptide transport  definition   [KW-0571]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAP2
GenomeRNAi: 6891
PRO: PR:Q03519