ATP7A - Copper-transporting ATPase 1 - human protein (Function)
 
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Protein
Gene
References

 
ATP7A »  Copper-transporting ATPase 1   [ EC 3.6.3.54 ]
 
Protein also known as:  Menkes disease-associated protein.
Gene name:  ATP7A
Entry whose protein(s) existence is based on evidence at protein level
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1 117 6
GENE REF ISO

Function

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Overview 
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.5.6  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • TASHGNC
Copper ion bindingdefinition[GO:0005507]  
1
  • IDAUniProtKB
Copper ion transmembrane transporter activitydefinition[GO:0005375]  
  • ISSOrtholog Curator
Copper-dependent protein bindingdefinition[GO:0032767]  
1
  • IPIUniProtKB
Copper-exporting ATPase activitydefinition[GO:0004008]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Superoxide dismutase copper chaperone activitydefinition[GO:0016532]  
  • ISSOrtholog Curator
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • ISSOrtholog Curator
Blood vessel developmentdefinition[GO:0001568]  
  • ISSOrtholog Curator
Blood vessel remodelingdefinition[GO:0001974]  
  • ISSOrtholog Curator
Cartilage developmentdefinition[GO:0051216]  
  • ISSOrtholog Curator
Catecholamine metabolic processdefinition[GO:0006584]  
  • ISSOrtholog Curator
Cellular copper ion homeostasisdefinition[GO:0006878]  
1
  • IMPUniProtKB
Central nervous system neuron developmentdefinition[GO:0021954]  
  • ISSOrtholog Curator
Cerebellar Purkinje cell differentiationdefinition[GO:0021702]  
  • ISSOrtholog Curator
Collagen fibril organizationdefinition[GO:0030199]  
  • ISSOrtholog Curator
Copper ion exportdefinition[GO:0060003]  
  • ISSOrtholog Curator
Copper ion importdefinition[GO:0015677]  
  • ISSOrtholog Curator
Copper ion transportdefinition[GO:0006825]  
1
  • IMPUniProtKB
Dendrite morphogenesisdefinition[GO:0048813] silver  
  • IEAOrtholog Compara
Detoxification of copper iondefinition[GO:0010273]  
  • ISSOrtholog Curator
Dopamine metabolic processdefinition[GO:0042417]  
  • ISSOrtholog Curator
Elastic fiber assemblydefinition[GO:0048251]  
  • ISSOrtholog Curator
Elastin biosynthetic processdefinition[GO:0051542]  
  • ISSOrtholog Curator
Epinephrine metabolic processdefinition[GO:0042414]  
  • ISSOrtholog Curator
Extracellular matrix organizationdefinition[GO:0030198]  
  • ISSOrtholog Curator
Hair follicle morphogenesisdefinition[GO:0031069]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Locomotory behaviordefinition[GO:0007626]  
  • ISSOrtholog Curator
Lung alveolus developmentdefinition[GO:0048286]  
  • ISSOrtholog Curator
Mitochondrion organizationdefinition[GO:0007005]  
  • ISSOrtholog Curator
Negative regulation of metalloenzyme activitydefinition[GO:0048553]  
  • ISSOrtholog Curator
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
  • ISSOrtholog Curator
Norepinephrine biosynthetic processdefinition[GO:0042421] silver  
  • IEAOrtholog Compara
Norepinephrine metabolic processdefinition[GO:0042415]  
  • ISSOrtholog Curator
Peptidyl-lysine modificationdefinition[GO:0018205]  
  • ISSOrtholog Curator
Pigmentationdefinition[GO:0043473]  
  • ISSOrtholog Curator
Positive regulation of catalytic activitydefinition[GO:0043085]  
  • ISSOrtholog Curator
Positive regulation of metalloenzyme activitydefinition[GO:0048554]  
  • ISSOrtholog Curator
Positive regulation of oxidoreductase activitydefinition[GO:0051353]  
1
  • IDAUniProtKB
Pyramidal neuron developmentdefinition[GO:0021860]  
  • ISSOrtholog Curator
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Regulation of oxidative phosphorylationdefinition[GO:0002082]  
  • ISSOrtholog Curator
Release of cytochrome c from mitochondriadefinition[GO:0001836] silver  
  • IEAOrtholog Compara
Removal of superoxide radicalsdefinition[GO:0019430]  
  • ISSOrtholog Curator
Response to iron(III) iondefinition[GO:0010041] silver  
  • IEAOrtholog Compara
Response to zinc iondefinition[GO:0010043] silver  
  • IEAOrtholog Compara
Serotonin metabolic processdefinition[GO:0042428]  
  • ISSOrtholog Curator
Skin developmentdefinition[GO:0043588]  
  • ISSOrtholog Curator
T-helper cell differentiationdefinition[GO:0042093]  
  • ISSOrtholog Curator
Tryptophan metabolic processdefinition[GO:0006568]  
  • ISSOrtholog Curator
Tyrosine metabolic processdefinition[GO:0006570] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.54: ATP + H(2)O + Cu(+)(Side 1) ADP + phosphate + Cu(+)(Side 2).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+538  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Copper transport  definition   [KW-0187]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP7A
GenomeRNAi: 538
PRO: PR:Q04656