OCA2 - P protein - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
OCA2 »  P protein
 
Protein also known as:  Melanocyte-specific transporter protein.
Gene name:  OCA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 3
GENE REF ISO

Function

 show evidences
Overview 
Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the arsenite-antimonite (arsb) efflux family  2.A.45.2.1  
GO molecular function 
L-tyrosine transmembrane transporter activitydefinition[GO:0005302]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Transporter activitydefinition[GO:0005215]  
2
  • TASPINC
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Eye pigment biosynthetic processdefinition[GO:0006726]  
1
  • TASPINC
Melanin biosynthetic processdefinition[GO:0042438] silver  
  • IEAOrtholog Compara
Melanocyte differentiationdefinition[GO:0030318] silver  
  • IEAOrtholog Compara
Spermatid developmentdefinition[GO:0007286] silver  
  • IEAOrtholog Compara
Transmembrane transportdefinition[GO:0055085] silver  
  • IEAInterPro 2 GO
Tyrosine transportdefinition[GO:0015828]  
1
  • TASGOC
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: OCA2
GenomeRNAi: 4948
PRO: PR:Q04671