TLE1 - Transducin-like enhancer protein 1 - human protein (Function)
 
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Protein
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TLE1 »  Transducin-like enhancer protein 1
 
Protein also known as:  Enhancer of split groucho-like protein 1 (ESG1).
Gene name:  TLE1
Family name: WD repeat Groucho/TLE
Entry whose protein(s) existence is based on evidence at protein level
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1 53 1
GENE REF ISO

Function

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Overview 
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
RNA polymerase II transcription corepressor activitydefinition[GO:0001106]  
1
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
2
  • IDAUniProtKB
GO biological process 
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of anoikisdefinition[GO:2000811]  
2
  • IMPUniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
1
  • NASUniProtKB
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
deactivation of the beta-catenin transactivating complex  REACT_200731  
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TLE1
GenomeRNAi: 7088
PRO: PR:Q04724