ACVR1 - Activin receptor type-1 - human protein (Function)
 
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ACVR1 »  Activin receptor type-1   [ EC 2.7.11.30 ]
 
Protein also known as:  Serine/threonine-protein kinase receptor R1 (SKR1).
Gene name:  ACVR1
Entry whose protein(s) existence is based on evidence at protein level
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1 68 1
GENE REF ISO

Function

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Overview 
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185]  
1
  • IDAUniProtKB
Contributes to activin receptor activity, type Idefinition[GO:0016361]  
1
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • IDAHGNC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Peptide hormone bindingdefinition[GO:0017046]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIBHF-UCL
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Protein kinase activitydefinition[GO:0004672]  
1
  • IDABHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAHGNC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAOrtholog Compara
SMAD bindingdefinition[GO:0046332]  
1
  • IDAHGNC
Transforming growth factor beta bindingdefinition[GO:0050431]  
1
  • IDAUniProtKB
Transforming growth factor beta receptor activity, type Idefinition[GO:0005025] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
1
  • RCAUniProtKB
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IDABHF-UCL
Acute inflammatory responsedefinition[GO:0002526] silver  
  • IEAOrtholog Compara
Atrial septum primum morphogenesisdefinition[GO:0003289]  
1
  • IMPBHF-UCL
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IDABHF-UCL
Cardiac muscle cell fate commitmentdefinition[GO:0060923]  
1
  • IMPBHF-UCL
Cellular response to glucocorticoid stimulusdefinition[GO:0071385] silver  
  • IEAOrtholog Compara
Determination of left/right symmetrydefinition[GO:0007368] silver  
  • IEAOrtholog Compara
Embryonic heart tube morphogenesisdefinition[GO:0003143]  
1
  • IMPBHF-UCL
Endocardial cushion cell fate commitmentdefinition[GO:0061445]  
1
  • IMPBHF-UCL
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IMPHGNC
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
  • IEAOrtholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Mitral valve morphogenesisdefinition[GO:0003183]  
1
  • IMPBHF-UCL
Negative regulation of activin receptor signaling pathwaydefinition[GO:0032926]  
1
  • IMPHGNC
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • IMPBHF-UCL
Negative regulation of signal transductiondefinition[GO:0009968]  
1
  • IMPHGNC
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
1
  • IDABHF-UCL
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • IDABHF-UCL
Pharyngeal system developmentdefinition[GO:0060037] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IMPBHF-UCL
Positive regulation of determination of dorsal identitydefinition[GO:2000017]  
1
  • IDABHF-UCL
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDABHF-UCL
  • IDAHGNC
Regulation of ossificationdefinition[GO:0030278]  
1
  • IMPUniProtKB
Regulation of skeletal muscle tissue developmentdefinition[GO:0048641] silver  
  • IEAOrtholog Compara
Smooth muscle cell differentiationdefinition[GO:0051145] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDAUniProtKB
Urogenital system developmentdefinition[GO:0001655] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+90  
TGF-beta signaling pathway  hsa04350+90  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACVR1
GenomeRNAi: 90
PRO: PR:Q04771
Chemistry
GuidetoPHARMACOLOGY: 1785