AKR1C1 - Aldo-keto reductase family 1 member C1 - human protein (Function)
 
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AKR1C1 »  Aldo-keto reductase family 1 member C1   [ EC 1.1.1.- ]
 
Protein also known as:  Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC 1.3.1.20].
Gene name:  AKR1C1
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 1
GENE REF ISO

Function

 show evidences
Overview 
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.  
3
  • UniProtKB
GO molecular function 
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activitydefinition[GO:0047006]  
1
  • EC 2 GO
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • UniProtKB
Aldo-keto reductase (NADP) activitydefinition[GO:0004033]  
1
  • UniProtKB
Androsterone dehydrogenase (B-specific) activitydefinition[GO:0047042]  
1
  • UniProtKB
Bile acid bindingdefinition[GO:0032052]  
1
  • UniProtKB
Carboxylic acid bindingdefinition[GO:0031406]  
1
  • UniProtKB
Indanol dehydrogenase activitydefinition[GO:0047718]  
1
  • EC 2 GO
Ketosteroid monooxygenase activitydefinition[GO:0047086]  
1
  • UniProtKB
Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptordefinition[GO:0016655]  
2
  • UniProtKB
Phenanthrene 9,10-monooxygenase activitydefinition[GO:0018636]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activitydefinition[GO:0047115]  
1
  • UniProtKB
GO biological process 
Bile acid and bile salt transportdefinition[GO:0015721]  
1
  • UniProtKB
Bile acid metabolic processdefinition[GO:0008206]  
1
  • UniProtKB
Cellular response to jasmonic acid stimulusdefinition[GO:0071395]  
1
  • UniProtKB
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • UniProtKB
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • UniProtKB
Digestiondefinition[GO:0007586]  
1
  • UniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • UniProtKB
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • UniProtKB
Intestinal cholesterol absorptiondefinition[GO:0030299]  
1
  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
3
  • UniProtKB
Progesterone metabolic processdefinition[GO:0042448]  
1
  • UniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • UniProtKB
Response to organophosphorusdefinition[GO:0046683]  
1
  • UniProtKB
Retinal metabolic processdefinition[GO:0042574]  
1
  • UniProtKB
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.149: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) 17-alpha-hydroxyprogesterone + NAD(P)H.  
1
  • UniProtKB
EC 1.3.1.20: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) catechol + NADPH.  
1
  • UniProtKB
EC 1.1.1.112: Indan-1-ol + NAD(P)(+) indanone + NAD(P)H.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an IC(50) of 55 uM, 1,7-phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0 uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid with an IC(50) of 570 uM.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolism of xenobiotics by cytochrome P450  hsa00980+1645  
Steroid hormone biosynthesis  hsa00140+1645  
According to Reactome, this protein belongs to the following pathways:
Retinoid metabolism and transport  REACT_24968  
Synthesis of bile acids and bile salts via 24-hydroxycholesterol  REACT_11053  
Synthesis of bile acids and bile salts via 27-hydroxycholesterol  REACT_11048  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  REACT_11041  
 

Biophysicochemical properties

Kinetic parameters
KM 133 uM for 9-alpha,11-beta-PGF2
KM 580 uM for benzene dihydrodiol
KM 3 uM for 5-beta-pregnane-3-alpha,20-alpha-diol
KM 0.6 uM for 20-alpha-hydroxyprogesterone (with NADH)
KM 12 uM for 4-pregnen-20-alpha-ol-3-one
KM 38 uM for (s)-indan-1-ol
KM 5 uM for (s)-tetralol
KM 1 uM for 5-beta-androstane-3,17-dione
KM 12 uM for PGD2
KM 2 uM for 5-beta-pregnan-3-alpha-ol-20-one
KM 3 uM for 5-beta-pregnan-20-alpha-ol-3-one

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q04828
Other
GeneWiki: AKR1C1
GenomeRNAi: 1645
PRO: PR:Q04828