AKR1C1 - Aldo-keto reductase family 1 member C1 - human protein (Function)
 
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AKR1C1 »  Aldo-keto reductase family 1 member C1   [ EC 1.1.1.- ]
 
Protein also known as:  Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC 1.3.1.20].
Gene name:  AKR1C1
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
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1 55 1
GENE REF ISO

Function

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Overview 
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.  
2
  • CuratedUniProtKB
GO molecular function 
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activitydefinition[GO:0047006]  
  • IEAEC 2 GO
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • IDAUniProtKB
Aldo-keto reductase (NADP) activitydefinition[GO:0004033]  
1
  • TASUniProtKB
Androsterone dehydrogenase (B-specific) activitydefinition[GO:0047042]  
1
  • IDAUniProtKB
Bile acid bindingdefinition[GO:0032052]  
1
  • IDAUniProtKB
Carboxylic acid bindingdefinition[GO:0031406]  
1
  • IDAUniProtKB
Indanol dehydrogenase activitydefinition[GO:0047718]  
  • IEAEC 2 GO
Ketosteroid monooxygenase activitydefinition[GO:0047086]  
1
  • IDAUniProtKB
Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptordefinition[GO:0016655]  
2
  • IDAUniProtKB
Phenanthrene 9,10-monooxygenase activitydefinition[GO:0018636]  
1
  • IDAUniProtKB
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activitydefinition[GO:0047115]  
1
  • IDAUniProtKB
GO biological process 
Bile acid and bile salt transportdefinition[GO:0015721]  
1
  • TASUniProtKB
Bile acid metabolic processdefinition[GO:0008206]  
1
  • IDAUniProtKB
Cellular response to jasmonic acid stimulusdefinition[GO:0071395]  
1
  • IDAUniProtKB
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • TASUniProtKB
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • IMPUniProtKB
Digestiondefinition[GO:0007586]  
1
  • IDAUniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • IMPUniProtKB
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IDAUniProtKB
Intestinal cholesterol absorptiondefinition[GO:0030299]  
1
  • TASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
3
  • IDAUniProtKB
Progesterone metabolic processdefinition[GO:0042448]  
1
  • IDAUniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Response to organophosphorusdefinition[GO:0046683]  
1
  • IEPUniProtKB
Retinal metabolic processdefinition[GO:0042574]  
1
  • IDAUniProtKB
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.149: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) 17-alpha-hydroxyprogesterone + NAD(P)H.  
2
  • CuratedUniProtKB
EC 1.3.1.20: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) catechol + NADPH.  
2
  • CuratedUniProtKB
EC 1.1.1.112: Indan-1-ol + NAD(P)(+) indanone + NAD(P)H.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an IC(50) of 55 uM, 1,7-phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0 uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid with an IC(50) of 570 uM.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolism of xenobiotics by cytochrome P450  hsa00980+1645  
Steroid hormone biosynthesis  hsa00140+1645  
According to Reactome, this protein belongs to the following pathways:
Retinoid metabolism and transport  REACT_24968  
Synthesis of bile acids and bile salts via 24-hydroxycholesterol  REACT_11053  
Synthesis of bile acids and bile salts via 27-hydroxycholesterol  REACT_11048  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  REACT_11041  
 

Biophysicochemical properties

Kinetic parameters
KM 133 uM for 9-alpha,11-beta-PGF2
KM 580 uM for benzene dihydrodiol
KM 3 uM for 5-beta-pregnane-3-alpha,20-alpha-diol
KM 0.6 uM for 20-alpha-hydroxyprogesterone (with NADH)
KM 12 uM for 4-pregnen-20-alpha-ol-3-one
KM 38 uM for (s)-indan-1-ol
KM 5 uM for (s)-tetralol
KM 1 uM for 5-beta-androstane-3,17-dione
KM 12 uM for PGD2
KM 2 uM for 5-beta-pregnan-3-alpha-ol-20-one
KM 3 uM for 5-beta-pregnan-20-alpha-ol-3-one

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q04828
Other
GeneWiki: AKR1C1
GenomeRNAi: 1645
PRO: PR:Q04828