CHRNE - Acetylcholine receptor subunit epsilon - human protein (Function)
 
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Protein
Gene
References

 
CHRNE »  Acetylcholine receptor subunit epsilon
 
Gene name:  CHRNE
Entry whose protein(s) existence is based on evidence at protein level
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1 35 1
GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.1  
GO molecular function 
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • TASPINC
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889] silver  
  • IEAOrtholog Compara
Cation transmembrane transporter activitydefinition[GO:0008324]  
1
  • TASPINC
GO biological process 
Cation transportdefinition[GO:0006812]  
2
  • TASGOC
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Regulation of membrane potentialdefinition[GO:0042391] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Synaptic transmission, cholinergicdefinition[GO:0007271]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1145  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CHRNE
GenomeRNAi: 1145
PRO: PR:Q04844