CD164 - Sialomucin core protein 24 - human protein (Function)
 
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CD164 »  Sialomucin core protein 24
 
Protein also known as:  CD antigen CD164.
Gene name:  CD164
Family name: CD164
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 5
GENE REF ISO

Function

 show evidences
Overview 
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • IDAMGI
Hemopoiesisdefinition[GO:0030097]  
1
  • NASUniProtKB
Heterophilic cell-cell adhesiondefinition[GO:0007157]  
1
  • IDAMGI
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Muscle organ developmentdefinition[GO:0007517]  
  • IEAUniProtKB KW
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • NASUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • NASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+8763  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Myogenesis  definition   [KW-0517]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD164
GenomeRNAi: 8763
PRO: PR:Q04900