MST1R - Macrophage-stimulating protein receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MST1R »  Macrophage-stimulating protein receptor   [ EC 2.7.10.1 ]  (MSP receptor)
 
Protein also known as:  Protein-tyrosine kinase 8; CD antigen CD136. Cleaved into:  Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain.
Gene name:  MST1R
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 111 6
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Macrophage colony-stimulating factor receptor activitydefinition[GO:0005011]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Defense responsedefinition[GO:0006952]  
1
  • TASPINC
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Macrophage colony-stimulating factor signaling pathwaydefinition[GO:0038145]  
1
  • TASGOC
Multicellular organismal developmentdefinition[GO:0007275] silver  
  • IEAInterPro 2 GO
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • TASGOC
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • IDAUniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDAUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Single fertilizationdefinition[GO:0007338]  
1
  • TASPINC
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MST1R
GenomeRNAi: 4486
PRO: PR:Q04912
Chemistry
GuidetoPHARMACOLOGY: 1816