YWHAH - 14-3-3 protein eta - human protein (Function)
 
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YWHAH »  14-3-3 protein eta
 
Protein also known as:  Protein AS1.
Gene name:  YWHAH
Family name: 14-3-3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 76 1
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Glucocorticoid receptor bindingdefinition[GO:0035259]  
1
  • IPIUniProtKB
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
  • ISSOrtholog Curator
Ion channel bindingdefinition[GO:0044325]  
2
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
21
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
  • ISSOrtholog Curator
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Sodium channel regulator activitydefinition[GO:0017080]  
1
  • IDABHF-UCL
GO biological process 
Glucocorticoid catabolic processdefinition[GO:0006713]  
1
  • IDAUniProtKB
Glucocorticoid receptor signaling pathwaydefinition[GO:0042921]  
1
  • IDAUniProtKB
Intracellular protein transportdefinition[GO:0006886]  
  • ISSOrtholog Curator
Membrane depolarization during action potentialdefinition[GO:0086010]  
1
  • IDABHF-UCL
Negative regulation of dendrite morphogenesisdefinition[GO:0050774]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of neuron differentiationdefinition[GO:0045664]  
  • ISSOrtholog Curator
Regulation of sodium ion transmembrane transporter activitydefinition[GO:2000649]  
1
  • IDABHF-UCL
Regulation of sodium ion transportdefinition[GO:0002028]  
1
  • IDABHF-UCL
Regulation of synaptic plasticitydefinition[GO:0048167]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+7533  
Neurotrophin signaling pathway  hsa04722+7533  
Oocyte meiosis  hsa04114+7533  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Membrane Trafficking  REACT_11123  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: YWHAH
GenomeRNAi: 7533
PRO: PR:Q04917