SRY - Sex-determining region Y protein - human protein (Function)
 
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SRY »  Sex-determining region Y protein
 
Protein also known as:  Testis-determining factor.
Gene name:  SRY
Family name: SRY
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  
5
  • UniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB KW
DNA bindingdefinition[GO:0003677]  
2
  • UniProtKB
DNA binding, bendingdefinition[GO:0008301] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Male sex determinationdefinition[GO:0030238]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Positive regulation of male gonad developmentdefinition[GO:2000020]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • GOC
  • Ortholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Sexual differentiation  definition   [KW-0726]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SRY
GenomeRNAi: 6736
PRO: PR:Q05066