ZBTB16 - Zinc finger and BTB domain-containing protein 16 - human protein (Function)
 
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ZBTB16 »  Zinc finger and BTB domain-containing protein 16
 
Protein also known as:  Promyelocytic leukemia zinc finger protein.
Gene name:  ZBTB16
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  
2
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • MGI
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • NTNU_SB
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001206]  
1
  • NTNU_SB
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cartilage developmentdefinition[GO:0051216]  
1
  • UniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • UniProtKB
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
1
  • Ortholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
1
  • Ortholog Compara
Embryonic pattern specificationdefinition[GO:0009880] silver  
1
  • Ortholog Compara
Forelimb morphogenesisdefinition[GO:0035136] silver  
1
  • Ortholog Compara
Hemopoiesisdefinition[GO:0030097]  
2
  • UniProtKB
Male germ-line stem cell asymmetric divisiondefinition[GO:0048133] silver  
1
  • Ortholog Compara
Mesonephros developmentdefinition[GO:0001823]  
1
  • UniProtKB
Myeloid cell differentiationdefinition[GO:0030099]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of myeloid cell differentiationdefinition[GO:0045638]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • NTNU_SB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • MGI
  • UniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • UniProtKB
Positive regulation of chondrocyte differentiationdefinition[GO:0032332]  
1
  • UniProtKB
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • UniProtKB
Positive regulation of NK T cell differentiationdefinition[GO:0051138] silver  
1
  • Ortholog Compara
Positive regulation of ossificationdefinition[GO:0045778]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Protein localization to nucleusdefinition[GO:0034504] silver  
1
  • Ortholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
1
  • UniPathway
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links