ZBTB16 - Zinc finger and BTB domain-containing protein 16 - human protein (Function)
 
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ZBTB16 »  Zinc finger and BTB domain-containing protein 16
 
Protein also known as:  Promyelocytic leukemia zinc finger protein.
Gene name:  ZBTB16
Entry whose protein(s) existence is based on evidence at protein level
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1 85 2
GENE REF ISO

Function

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Overview 
Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • IDAMGI
  • NASUniProtKB
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Cartilage developmentdefinition[GO:0051216]  
1
  • IDAUniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • ISSUniProtKB
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Embryonic pattern specificationdefinition[GO:0009880] silver  
  • IEAOrtholog Compara
Forelimb morphogenesisdefinition[GO:0035136] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097]  
2
  • TASUniProtKB
Male germ-line stem cell divisiondefinition[GO:0048133] silver  
  • IEAOrtholog Compara
Mesonephros developmentdefinition[GO:0001823]  
1
  • ISSUniProtKB
Myeloid cell differentiationdefinition[GO:0030099]  
1
  • TASUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of myeloid cell differentiationdefinition[GO:0045638]  
1
  • ISSUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • IDAMGI
  • NASUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • IDAUniProtKB
Positive regulation of chondrocyte differentiationdefinition[GO:0032332]  
1
  • IMPUniProtKB
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • IMPUniProtKB
Positive regulation of ossificationdefinition[GO:0045778]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein localization to nucleusdefinition[GO:0034504] silver  
  • IEAOrtholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links