SLC18A2 - Synaptic vesicular amine transporter - human protein (Function)
 
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Protein
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SLC18A2 »  Synaptic vesicular amine transporter
 
Protein also known as:  Solute carrier family 18 member 2.
Gene name:  SLC18A2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.2.29  
GO molecular function 
Amine transmembrane transporter activitydefinition[GO:0005275] silver  
  • IEAOrtholog Compara
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Heat shock protein bindingdefinition[GO:0031072] silver  
  • IEAOrtholog Compara
Monoamine transmembrane transporter activitydefinition[GO:0008504]  
1
  • TASPINC
Serotonin transmembrane transporter activitydefinition[GO:0015222] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Amine transportdefinition[GO:0015837]  
  • IEAOrtholog Compara
Cellular response to ammonium iondefinition[GO:0071242] silver  
  • IEAOrtholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
  • IEAOrtholog Compara
Deathdefinition[GO:0016265] silver  
  • IEAOrtholog Compara
Endocytic recyclingdefinition[GO:0032456] silver  
  • IEAOrtholog Compara
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Monoamine transportdefinition[GO:0015844]  
1
  • TASPINC
Negative regulation of neurotransmitter transportdefinition[GO:0051589] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Response to herbicidedefinition[GO:0009635] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Response to zinc iondefinition[GO:0010043] silver  
  • IEAOrtholog Compara
Serotonin transportdefinition[GO:0006837] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+6571  
Parkinson's disease  hsa05012+6571  
Synaptic vesicle cycle  hsa04721+6571  
According to Reactome, this protein belongs to the following pathways:
Dopamine Neurotransmitter Release Cycle  REACT_15293  
Na+/Cl- dependent neurotransmitter transporters  REACT_20506  
Norepinephrine Neurotransmitter Release Cycle  REACT_15418  
Serotonin Neurotransmitter Release Cycle  REACT_15425  
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Vesicular_monoamine_transporter_2
GenomeRNAi: 6571
PRO: PR:Q05940
Chemistry
GuidetoPHARMACOLOGY: 1012