SLC18A2 - Synaptic vesicular amine transporter - human protein (Function)
 
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SLC18A2 »  Synaptic vesicular amine transporter
 
Protein also known as:  Solute carrier family 18 member 2.
Gene name:  SLC18A2
Entry whose protein(s) existence is based on evidence at protein level
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1 85 2
GENE REF ISO

Function

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Overview 
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.2.29  
GO molecular function 
Monoamine transmembrane transporter activitydefinition[GO:0008504]  
1
  • PINC
GO biological process 
Deathdefinition[GO:0016265] silver  
1
  • Ortholog Compara
Dopamine transportdefinition[GO:0015872]  
1
  • ParkinsonsUK-UCL
Locomotory behaviordefinition[GO:0007626] silver  
1
  • Ortholog Compara
Monoamine transportdefinition[GO:0015844]  
1
  • PINC
Negative regulation of reactive oxygen species biosynthetic processdefinition[GO:1903427]  
1
  • ParkinsonsUK-UCL
Neurotransmitter loading into synaptic vesicledefinition[GO:0098700]  
1
  • ParkinsonsUK-UCL
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Sequestering of neurotransmitterdefinition[GO:0042137]  
1
  • ParkinsonsUK-UCL
Synaptic transmissiondefinition[GO:0007268]  
1
  • ParkinsonsUK-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+6571  
Parkinson's disease  hsa05012+6571  
Synaptic vesicle cycle  hsa04721+6571  
According to Reactome, this protein belongs to the following pathways:
Dopamine Neurotransmitter Release Cycle  R-HSA-212676  
Na+/Cl- dependent neurotransmitter transporters  R-HSA-442660  
Norepinephrine Neurotransmitter Release Cycle  R-HSA-181430  
Serotonin Neurotransmitter Release Cycle  R-HSA-181429  
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Vesicular_monoamine_transporter_2
GenomeRNAi: 6571
PRO: PR:Q05940
Chemistry
GuidetoPHARMACOLOGY: 1012