ATP5G2 - ATP synthase F(0) complex subunit C2, mitochondrial - human protein (Function)
 
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ATP5G2 »  ATP synthase F(0) complex subunit C2, mitochondrial
 
Protein also known as:  ATP synthase proton-transporting mitochondrial F(0) complex subunit C2.
Gene name:  ATP5G2
Family name: ATPase C chain
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 9 3
GENE REF ISO

Function

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Overview 
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.  
  • CuratedUniProtKB
GO molecular function 
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAInterPro 2 GO
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
Transporter activitydefinition[GO:0005215]  
1
  • NASPINC
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
ATP synthesis coupled proton transportdefinition[GO:0015986] silver  
  • IEAInterPro 2 GO
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+517  
Huntington's disease  hsa05016+517  
Metabolic pathways  hsa01100+517  
Oxidative phosphorylation  hsa00190+517  
Parkinson's disease  hsa05012+517  
Note 
There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP5G2
GenomeRNAi: 517
PRO: PR:Q06055