PPAT - Amidophosphoribosyltransferase - human protein (Function)
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PPAT »  Amidophosphoribosyltransferase   [ EC ]  (ATase)
Protein also known as:  Glutamine phosphoribosylpyrophosphate amidotransferase (GPAT).
Gene name:  PPAT
Family name: In the C-terminal section Purine/pyrimidine phosphoribosyltransferase
Entry whose protein(s) existence is based on evidence at protein level
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GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB KW
Amidophosphoribosyltransferase activitydefinition[GO:0004044]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
'de novo' IMP biosynthetic processdefinition[GO:0006189]  
  • IEAUniPathway
Cellular response to drugdefinition[GO:0035690] silver  
  • IEAOrtholog Compara
Cellular response to insulin stimulusdefinition[GO:0032869] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Glutamine catabolic processdefinition[GO:0006543] silver  
  • IEAOrtholog Compara
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
  • IEAOrtholog Compara
Nucleoside metabolic processdefinition[GO:0009116] silver  
  • IEAInterPro 2 GO
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Purine nucleobase biosynthetic processdefinition[GO:0009113] silver  
  • IEAInterPro 2 GO
Purine nucleotide biosynthetic processdefinition[GO:0006164]  
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 magnesium ion per subunit (By similarity).  
  • CuratedUniProtKB
Binds 1 4Fe-4S cluster per subunit (By similarity).  
  • CuratedUniProtKB
More information is available from:
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+5471  
Metabolic pathways  hsa01100+5471  
Purine metabolism  hsa00230+5471  
According to Reactome, this protein belongs to the following pathway:
Purine ribonucleoside monophosphate biosynthesis  REACT_1776  
More information is available from:


Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Amidophosphoribosyltransferase
GenomeRNAi: 5471
PRO: PR:Q06203