EXOSC9 - Exosome complex component RRP45 - human protein (Function)
 
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EXOSC9 »  Exosome complex component RRP45
 
Protein also known as:  P75 polymyositis-scleroderma overlap syndrome-associated autoantigen.
Gene name:  EXOSC9
Family name: RNase PH
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.  
5
  • UniProtKB
GO molecular function 
3'-5'-exoribonuclease activitydefinition[GO:0000175]  
1
  • UniProtKB
AU-rich element bindingdefinition[GO:0017091]  
1
  • UniProtKB
Not  Exoribonuclease activitydefinition[GO:0004532]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
RNA bindingdefinition[GO:0003723]  
1
  • UniProtKB
GO biological process 
Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decaydefinition[GO:0043928]  
1
  • UniProtKB
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)definition[GO:0000467]  
1
  • RefGenome
Immune responsedefinition[GO:0006955]  
1
  • UniProtKB
Nuclear mRNA surveillancedefinition[GO:0071028]  
1
  • UniProtKB
Nuclear polyadenylation-dependent mRNA catabolic processdefinition[GO:0071042]  
1
  • RefGenome
Nuclear polyadenylation-dependent rRNA catabolic processdefinition[GO:0071035]  
1
  • UniProtKB
Nuclear polyadenylation-dependent tRNA catabolic processdefinition[GO:0071038]  
1
  • RefGenome
Nuclear-transcribed mRNA catabolic processdefinition[GO:0000956]  
1
  • UniProtKB
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'definition[GO:0034427]  
1
  • RefGenome
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • UniProtKB
rRNA processingdefinition[GO:0006364]  
1
  • UniProtKB
U1 snRNA 3'-end processingdefinition[GO:0034473]  
1
  • RefGenome
U4 snRNA 3'-end processingdefinition[GO:0034475]  
1
  • RefGenome
U5 snRNA 3'-end processingdefinition[GO:0034476]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+5393  
According to Reactome, this protein belongs to the following pathways:
ATF4 activates genes  R-HSA-380994  
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA  R-HSA-450385  
KSRP (KHSRP) binds and destabilizes mRNA  R-HSA-450604  
mRNA decay by 3' to 5' exoribonuclease  R-HSA-429958  
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA  R-HSA-450513  
Caution 
The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active.  
1
  • UniProtKB
 

Keywords

Biological process 
rRNA processing  definition   [KW-0698]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Exosome_component_9
GenomeRNAi: 5393
PRO: PR:Q06265