RBPJ - Recombining binding protein suppressor of hairless - human protein (Function)
 
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Protein
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RBPJ »  Recombining binding protein suppressor of hairless
 
Protein also known as:  J kappa-recombination signal-binding protein.
Gene name:  RBPJ
Family name: Su(H)
Entry whose protein(s) existence is based on evidence at protein level
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1 81 7
GENE REF ISO

Function

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Overview 
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Protein N-terminus bindingdefinition[GO:0047485] silver  
  • IEAOrtholog Compara
Recombinase activitydefinition[GO:0000150]  
1
  • NASUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAInterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IDAMGI
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
  • IEAOrtholog Compara
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • IPIBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Arterial endothelial cell fate commitmentdefinition[GO:0060844] silver  
  • IEAOrtholog Compara
Atrioventricular canal developmentdefinition[GO:0036302]  
  • ISSOrtholog Curator
Auditory receptor cell fate commitmentdefinition[GO:0009912] silver  
  • IEAOrtholog Compara
B cell differentiationdefinition[GO:0030183] silver  
  • IEAOrtholog Compara
Blood vessel endothelial cell fate specificationdefinition[GO:0097101]  
  • ISSOrtholog Curator
Blood vessel lumenizationdefinition[GO:0072554]  
  • ISSOrtholog Curator
Blood vessel remodelingdefinition[GO:0001974] silver  
  • IEAOrtholog Compara
Cardiac left ventricle morphogenesisdefinition[GO:0003214]  
  • ISSOrtholog Curator
Clara cell differentiationdefinition[GO:0060486] silver  
  • IEAOrtholog Compara
Defense response to bacteriumdefinition[GO:0042742] silver  
  • IEAOrtholog Compara
DNA recombinationdefinition[GO:0006310]  
1
  • NASUniProtKB
Dorsal aorta morphogenesisdefinition[GO:0035912]  
  • ISSOrtholog Curator
Endocardium morphogenesisdefinition[GO:0003160]  
  • ISSOrtholog Curator
Epidermal cell fate specificationdefinition[GO:0009957] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
  • ISSOrtholog Curator
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
  • ISSOrtholog Curator
Hair follicle maturationdefinition[GO:0048820] silver  
  • IEAOrtholog Compara
Humoral immune responsedefinition[GO:0006959] silver  
  • IEAOrtholog Compara
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
  • IEAOrtholog Compara
Interleukin-4 secretiondefinition[GO:0072602] silver  
  • IEAOrtholog Compara
Keratinocyte differentiationdefinition[GO:0030216] silver  
  • IEAOrtholog Compara
Labyrinthine layer blood vessel developmentdefinition[GO:0060716]  
  • ISSOrtholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of ossificationdefinition[GO:0030279]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Notch signaling involved in heart developmentdefinition[GO:0061314]  
1
  • ICBHF-UCL
Notch signaling pathwaydefinition[GO:0007219]  
1
  • IMPBHF-UCL
Outflow tract morphogenesisdefinition[GO:0003151]  
  • ISSOrtholog Curator
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
  • ISSOrtholog Curator
Positive regulation of cell proliferation involved in heart morphogenesisdefinition[GO:2000138]  
  • ISSOrtholog Curator
Positive regulation of ephrin receptor signaling pathwaydefinition[GO:1901189]  
  • ISSOrtholog Curator
Positive regulation of ERBB signaling pathwaydefinition[GO:1901186]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPBHF-UCL
Positive regulation of transcription of Notch receptor targetdefinition[GO:0007221]  
1
  • IDAUniProtKB
Regulation of timing of cell differentiationdefinition[GO:0048505] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationdefinition[GO:0003256]  
  • ISSOrtholog Curator
Sebaceous gland developmentdefinition[GO:0048733] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Ventricular trabecula myocardium morphogenesisdefinition[GO:0003222]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Notch signaling pathway  hsa04330+3516  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Gene Expression  REACT_71  
NICD traffics to nucleus  REACT_2155  
Signal Transduction  REACT_111102  
Caution 
Despite some similarity with the "phage" integrase family, it has no recombinase activity.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RBPJ
GenomeRNAi: 3516
PRO: PR:Q06330