RBPJ - Recombining binding protein suppressor of hairless - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
RBPJ »  Recombining binding protein suppressor of hairless
 
Protein also known as:  J kappa-recombination signal-binding protein.
Gene name:  RBPJ
Family name: Su(H)
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 7
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
Protein N-terminus bindingdefinition[GO:0047485] silver  
1
  • Ortholog Compara
Recombinase activitydefinition[GO:0000150]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • InterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • MGI
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • BHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • Ortholog Curator
Arterial endothelial cell fate commitmentdefinition[GO:0060844] silver  
1
  • Ortholog Compara
Atrioventricular canal developmentdefinition[GO:0036302]  
1
  • Ortholog Curator
Auditory receptor cell fate commitmentdefinition[GO:0009912] silver  
1
  • Ortholog Compara
B cell differentiationdefinition[GO:0030183] silver  
1
  • Ortholog Compara
Blood vessel endothelial cell fate specificationdefinition[GO:0097101]  
1
  • Ortholog Curator
Blood vessel lumenizationdefinition[GO:0072554]  
1
  • Ortholog Curator
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Cardiac left ventricle morphogenesisdefinition[GO:0003214]  
1
  • Ortholog Curator
Clara cell differentiationdefinition[GO:0060486] silver  
1
  • Ortholog Compara
Defense response to bacteriumdefinition[GO:0042742] silver  
1
  • Ortholog Compara
DNA recombinationdefinition[GO:0006310]  
1
  • UniProtKB
Dorsal aorta morphogenesisdefinition[GO:0035912]  
1
  • Ortholog Curator
Endocardium morphogenesisdefinition[GO:0003160]  
1
  • Ortholog Curator
Epidermal cell fate specificationdefinition[GO:0009957] silver  
1
  • Ortholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • Ortholog Curator
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
1
  • Ortholog Curator
Hair follicle maturationdefinition[GO:0048820] silver  
1
  • Ortholog Compara
Humoral immune responsedefinition[GO:0006959] silver  
1
  • Ortholog Compara
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
1
  • Ortholog Compara
Interleukin-4 secretiondefinition[GO:0072602] silver  
1
  • Ortholog Compara
Keratinocyte differentiationdefinition[GO:0030216] silver  
1
  • Ortholog Compara
Labyrinthine layer blood vessel developmentdefinition[GO:0060716]  
1
  • Ortholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of ossificationdefinition[GO:0030279]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • BHF-UCL
  • Ortholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Notch signaling involved in heart developmentdefinition[GO:0061314]  
1
  • BHF-UCL
Notch signaling pathwaydefinition[GO:0007219]  
1
  • BHF-UCL
Outflow tract morphogenesisdefinition[GO:0003151]  
1
  • Ortholog Curator
Pituitary gland developmentdefinition[GO:0021983] silver  
1
  • Ortholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
1
  • Ortholog Curator
Positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitmentdefinition[GO:1901297] silver  
1
  • Ortholog Compara
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
1
  • Ortholog Curator
Positive regulation of cell proliferation involved in heart morphogenesisdefinition[GO:2000138]  
1
  • Ortholog Curator
Positive regulation of ephrin receptor signaling pathwaydefinition[GO:1901189]  
1
  • Ortholog Curator
Positive regulation of ERBB signaling pathwaydefinition[GO:1901186]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
Positive regulation of transcription of Notch receptor targetdefinition[GO:0007221]  
1
  • UniProtKB
Regulation of timing of cell differentiationdefinition[GO:0048505] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationdefinition[GO:0003256]  
1
  • Ortholog Curator
Sebaceous gland developmentdefinition[GO:0048733] silver  
1
  • Ortholog Compara
Secondary heart field specificationdefinition[GO:0003139] silver  
1
  • Ortholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
1
  • Ortholog Compara
Ventricular trabecula myocardium morphogenesisdefinition[GO:0003222]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Notch signaling pathway  hsa04330+3516  
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
Notch-HLH transcription pathway  REACT_14835  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
NOTCH2 intracellular domain regulates transcription  REACT_163910  
Pre-NOTCH Transcription and Translation  REACT_118568  
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells  REACT_13673  
Caution 
Despite some similarity with the "phage" integrase family, it has no recombinase activity.  
1
  • UniProtKB
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RBPJ
GenomeRNAi: 3516
PRO: PR:Q06330