MEF2C - Myocyte-specific enhancer factor 2C - human protein (Function)
 
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MEF2C »  Myocyte-specific enhancer factor 2C
 
Gene name:  MEF2C
Family name: MEF2
Entry whose protein(s) existence is based on evidence at protein level
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1 88 6
GENE REF ISO

Function

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Overview 
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).  
6
  • CuratedUniProtKB
Isoforms  Iso 3 and Iso 4   Which lack the repressor domain, are more active than isoform 1 and isoform 2.  
6
  • CuratedUniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • IPIUniProtKB
AT DNA bindingdefinition[GO:0003680]  
1
  • IDAUniProtKB
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987] silver  
  • IEAOrtholog Compara
Core promoter sequence-specific DNA bindingdefinition[GO:0001046] silver  
  • IEAOrtholog Compara
Isoforms  Iso 1 and Iso 3   DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Histone deacetylase bindingdefinition[GO:0042826] silver  
  • IEAOrtholog Compara
HMG box domain bindingdefinition[GO:0071837] silver  
  • IEAOrtholog Compara
miRNA bindingdefinition[GO:0035198]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IDAUniProtKB
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activitydefinition[GO:0000983]  
1
  • IDAUniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IEAOrtholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDAUniProtKB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • ISSUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • ISSOrtholog Curator
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
B cell homeostasisdefinition[GO:0001782]  
  • ISSOrtholog Curator
B cell proliferationdefinition[GO:0042100]  
  • ISSOrtholog Curator
B cell receptor signaling pathwaydefinition[GO:0050853]  
  • ISSOrtholog Curator
Blood vessel developmentdefinition[GO:0001568]  
  • ISSOrtholog Curator
Blood vessel remodelingdefinition[GO:0001974]  
  • ISSOrtholog Curator
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898] silver  
  • IEAOrtholog Compara
Cardiac ventricle formationdefinition[GO:0003211]  
  • ISSOrtholog Curator
Cartilage morphogenesisdefinition[GO:0060536] silver  
  • IEAOrtholog Compara
Cellular response to calcium iondefinition[GO:0071277]  
  • ISSOrtholog Curator
Cellular response to drugdefinition[GO:0035690]  
  • ISSOrtholog Curator
Cellular response to fluid shear stressdefinition[GO:0071498]  
  • ISSOrtholog Curator
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
  • ISSOrtholog Curator
Cellular response to parathyroid hormone stimulusdefinition[GO:0071374]  
1
  • IDAUniProtKB
Cellular response to retinoic aciddefinition[GO:0071300] silver  
  • IEAOrtholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • IDAUniProtKB
Cellular response to trichostatin Adefinition[GO:0035984]  
  • ISSOrtholog Curator
Chondrocyte differentiationdefinition[GO:0002062]  
  • ISSOrtholog Curator
Dentate gyrus developmentdefinition[GO:0021542] silver  
  • IEAOrtholog Compara
Embryonic viscerocranium morphogenesisdefinition[GO:0048703] silver  
  • IEAOrtholog Compara
Endochondral ossificationdefinition[GO:0001958]  
  • ISSOrtholog Curator
Epithelial cell proliferation involved in renal tubule morphogenesisdefinition[GO:2001013]  
  • ISSOrtholog Curator
Germinal center formationdefinition[GO:0002467]  
  • ISSOrtholog Curator
Glomerulus morphogenesisdefinition[GO:0072102]  
  • ISSOrtholog Curator
Heart developmentdefinition[GO:0007507]  
2
  • NASUniProtKB
  • ISSOrtholog Curator
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Humoral immune responsedefinition[GO:0006959]  
  • ISSOrtholog Curator
Learning or memorydefinition[GO:0007611]  
  • ISSOrtholog Curator
MAPK cascadedefinition[GO:0000165]  
2
  • IMPUniProtKB
Melanocyte differentiationdefinition[GO:0030318]  
1
  • ISSUniProtKB
Monocyte differentiationdefinition[GO:0030224] silver  
  • IEAOrtholog Compara
Muscle cell fate determinationdefinition[GO:0007521]  
  • ISSOrtholog Curator
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASPINC
Myotube differentiationdefinition[GO:0014902]  
1
  • IEPUniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
  • ISSOrtholog Curator
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
  • ISSOrtholog Curator
Negative regulation of ossificationdefinition[GO:0030279]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
Nephron tubule epithelial cell differentiationdefinition[GO:0072160]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neural crest cell differentiationdefinition[GO:0014033]  
1
  • ISSUniProtKB
Neuron developmentdefinition[GO:0048666]  
  • ISSOrtholog Curator
Neuron differentiationdefinition[GO:0030182]  
1
  • IEPUniProtKB
  • ISSOrtholog Curator
Osteoblast differentiationdefinition[GO:0001649]  
  • ISSOrtholog Curator
Outflow tract morphogenesisdefinition[GO:0003151]  
  • ISSOrtholog Curator
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Platelet formationdefinition[GO:0030220]  
  • ISSOrtholog Curator
Positive regulation of alkaline phosphatase activitydefinition[GO:0010694]  
  • ISSOrtholog Curator
Positive regulation of B cell proliferationdefinition[GO:0030890]  
  • ISSOrtholog Curator
Positive regulation of behavioral fear responsedefinition[GO:2000987]  
  • ISSOrtholog Curator
Positive regulation of bone mineralizationdefinition[GO:0030501]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle cell differentiationdefinition[GO:2000727]  
1
  • IDAUniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferation in bone marrowdefinition[GO:0071864] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
2
  • IDAUniProtKB
Positive regulation of macrophage apoptotic processdefinition[GO:2000111]  
  • ISSOrtholog Curator
Positive regulation of myoblast differentiationdefinition[GO:0045663]  
1
  • IMPUniProtKB
Positive regulation of neuron differentiationdefinition[GO:0045666]  
  • ISSOrtholog Curator
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
  • ISSOrtholog Curator
Positive regulation of protein homodimerization activitydefinition[GO:0090073]  
  • ISSOrtholog Curator
Positive regulation of skeletal muscle cell differentiationdefinition[GO:2001016]  
1
  • IDAUniProtKB
Positive regulation of skeletal muscle tissue developmentdefinition[GO:0048643]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
5
  • IMPUniProtKB
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
Primary heart field specificationdefinition[GO:0003138]  
  • ISSOrtholog Curator
Regulation of germinal center formationdefinition[GO:0002634]  
  • ISSOrtholog Curator
Regulation of megakaryocyte differentiationdefinition[GO:0045652]  
  • ISSOrtholog Curator
Regulation of sarcomere organizationdefinition[GO:0060297] silver  
  • IEAOrtholog Compara
Regulation of synaptic activitydefinition[GO:0060025]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAAlzheimers_University_of_Toronto
Renal tubule morphogenesisdefinition[GO:0061333]  
  • ISSOrtholog Curator
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
Secondary heart field specificationdefinition[GO:0003139]  
  • ISSOrtholog Curator
Sinoatrial valve morphogenesisdefinition[GO:0003185]  
  • ISSOrtholog Curator
Skeletal muscle tissue developmentdefinition[GO:0007519]  
  • ISSOrtholog Curator
Smooth muscle cell differentiationdefinition[GO:0051145]  
  • ISSOrtholog Curator
Ventricular cardiac muscle cell differentiationdefinition[GO:0055012]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+4208  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MEF2C
GenomeRNAi: 4208
PRO: PR:Q06413