MEF2C - Myocyte-specific enhancer factor 2C - human protein (Function)
 
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MEF2C »  Myocyte-specific enhancer factor 2C
 
Gene name:  MEF2C
Family name: MEF2
Entry whose protein(s) existence is based on evidence at protein level
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1 92 6
GENE REF ISO

Function

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Overview 
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).  
6
  • UniProtKB
Isoforms  Iso 3 and Iso 4   Which lack the repressor domain, are more active than isoform 1 and isoform 2.  
7
  • UniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • UniProtKB
AT DNA bindingdefinition[GO:0003680]  
1
  • UniProtKB
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Core promoter sequence-specific DNA bindingdefinition[GO:0001046] silver  
1
  • Ortholog Compara
Isoforms  Iso 1 and Iso 3   DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Histone deacetylase bindingdefinition[GO:0042826] silver  
1
  • Ortholog Compara
HMG box domain bindingdefinition[GO:0071837] silver  
1
  • Ortholog Compara
miRNA bindingdefinition[GO:0035198]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • UniProtKB
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activitydefinition[GO:0000983]  
1
  • UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001205] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • UniProtKB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • BHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • Ortholog Curator
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
B cell homeostasisdefinition[GO:0001782]  
1
  • Ortholog Curator
B cell proliferationdefinition[GO:0042100]  
1
  • Ortholog Curator
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • Ortholog Curator
Blood vessel developmentdefinition[GO:0001568]  
1
  • Ortholog Curator
Blood vessel remodelingdefinition[GO:0001974]  
1
  • Ortholog Curator
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898] silver  
1
  • Ortholog Compara
Cardiac ventricle formationdefinition[GO:0003211]  
1
  • Ortholog Curator
Cartilage morphogenesisdefinition[GO:0060536] silver  
1
  • Ortholog Compara
Cell morphogenesis involved in neuron differentiationdefinition[GO:0048667]  
1
  • Ortholog Curator
Cellular response to calcium iondefinition[GO:0071277]  
1
  • Ortholog Curator
Cellular response to drugdefinition[GO:0035690]  
1
  • Ortholog Curator
Cellular response to fluid shear stressdefinition[GO:0071498]  
1
  • Ortholog Curator
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • Ortholog Curator
Cellular response to parathyroid hormone stimulusdefinition[GO:0071374]  
1
  • UniProtKB
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • UniProtKB
Cellular response to trichostatin Adefinition[GO:0035984]  
1
  • Ortholog Curator
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • Ortholog Curator
Embryonic viscerocranium morphogenesisdefinition[GO:0048703] silver  
1
  • Ortholog Compara
Endochondral ossificationdefinition[GO:0001958]  
1
  • Ortholog Curator
Epithelial cell proliferation involved in renal tubule morphogenesisdefinition[GO:2001013]  
1
  • Ortholog Curator
Germinal center formationdefinition[GO:0002467]  
1
  • Ortholog Curator
Glomerulus morphogenesisdefinition[GO:0072102]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507]  
3
  • UniProtKB
  • Ortholog Curator
Heart loopingdefinition[GO:0001947]  
1
  • Ortholog Curator
Humoral immune responsedefinition[GO:0006959]  
1
  • Ortholog Curator
Learning or memorydefinition[GO:0007611]  
1
  • Ortholog Curator
MAPK cascadedefinition[GO:0000165]  
2
  • UniProtKB
Melanocyte differentiationdefinition[GO:0030318]  
1
  • UniProtKB
Monocyte differentiationdefinition[GO:0030224] silver  
1
  • Ortholog Compara
Muscle cell fate determinationdefinition[GO:0007521]  
1
  • Ortholog Curator
Muscle organ developmentdefinition[GO:0007517]  
1
  • PINC
Myotube differentiationdefinition[GO:0014902]  
1
  • UniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • Ortholog Curator
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • Ortholog Curator
Negative regulation of ossificationdefinition[GO:0030279]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Nephron tubule epithelial cell differentiationdefinition[GO:0072160]  
1
  • Ortholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Neural crest cell differentiationdefinition[GO:0014033]  
1
  • UniProtKB
Neuron developmentdefinition[GO:0048666]  
1
  • Ortholog Curator
Neuron differentiationdefinition[GO:0030182]  
2
  • UniProtKB
  • Ortholog Curator
Neuron migrationdefinition[GO:0001764]  
1
  • Ortholog Curator
Osteoblast differentiationdefinition[GO:0001649]  
1
  • Ortholog Curator
Outflow tract morphogenesisdefinition[GO:0003151]  
1
  • Ortholog Curator
Palate developmentdefinition[GO:0060021] silver  
1
  • Ortholog Compara
Platelet formationdefinition[GO:0030220]  
1
  • Ortholog Curator
Positive regulation of alkaline phosphatase activitydefinition[GO:0010694]  
1
  • Ortholog Curator
Positive regulation of B cell proliferationdefinition[GO:0030890]  
1
  • Ortholog Curator
Positive regulation of behavioral fear responsedefinition[GO:2000987]  
1
  • Ortholog Curator
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • Ortholog Curator
Positive regulation of cardiac muscle cell differentiationdefinition[GO:2000727]  
1
  • UniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
1
  • Ortholog Curator
Positive regulation of cell proliferation in bone marrowdefinition[GO:0071864] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
2
  • UniProtKB
Positive regulation of macrophage apoptotic processdefinition[GO:2000111]  
1
  • Ortholog Curator
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • Ortholog Curator
Positive regulation of myoblast differentiationdefinition[GO:0045663]  
1
  • UniProtKB
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • Ortholog Curator
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • Ortholog Curator
Positive regulation of protein homodimerization activitydefinition[GO:0090073]  
1
  • Ortholog Curator
Positive regulation of skeletal muscle cell differentiationdefinition[GO:2001016]  
1
  • UniProtKB
Positive regulation of skeletal muscle tissue developmentdefinition[GO:0048643]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
5
  • UniProtKB
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
Primary heart field specificationdefinition[GO:0003138]  
1
  • Ortholog Curator
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]  
1
  • Ortholog Curator
Regulation of dendritic spine developmentdefinition[GO:0060998]  
1
  • Ortholog Curator
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079]  
1
  • Ortholog Curator
Regulation of germinal center formationdefinition[GO:0002634]  
1
  • Ortholog Curator
Regulation of megakaryocyte differentiationdefinition[GO:0045652]  
1
  • Ortholog Curator
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310]  
1
  • Ortholog Curator
Regulation of neuron apoptotic processdefinition[GO:0043523]  
1
  • Ortholog Curator
Regulation of neurotransmitter secretiondefinition[GO:0046928]  
1
  • Ortholog Curator
Regulation of sarcomere organizationdefinition[GO:0060297] silver  
1
  • Ortholog Compara
Regulation of synapse assemblydefinition[GO:0051963]  
1
  • Ortholog Curator
Regulation of synaptic activitydefinition[GO:0060025]  
1
  • Ortholog Curator
Regulation of synaptic plasticitydefinition[GO:0048167]  
1
  • Ortholog Curator
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Alzheimers_University_of_Toronto
Renal tubule morphogenesisdefinition[GO:0061333]  
1
  • Ortholog Curator
Response to ischemiadefinition[GO:0002931]  
1
  • Ortholog Curator
Response to virusdefinition[GO:0009615]  
1
  • UniProtKB
Secondary heart field specificationdefinition[GO:0003139]  
1
  • Ortholog Curator
Sinoatrial valve morphogenesisdefinition[GO:0003185]  
1
  • Ortholog Curator
Skeletal muscle tissue developmentdefinition[GO:0007519]  
1
  • Ortholog Curator
Smooth muscle cell differentiationdefinition[GO:0051145]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
3
  • GOC
  • Ortholog Compara
Ventricular cardiac muscle cell differentiationdefinition[GO:0055012]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+4208  
According to Reactome, this protein belongs to the following pathways:
CDO in myogenesis  REACT_21402  
Circadian Clock  REACT_24941  
ERK/MAPK targets  REACT_12599  
Transcriptional activation of mitochondrial biogenesis  REACT_264212  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MEF2C
GenomeRNAi: 4208
PRO: PR:Q06413