GABPA - GA-binding protein alpha chain - human protein (Function)
 
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References

 
GABPA »  GA-binding protein alpha chain  (GABP subunit alpha)
 
Protein also known as:  Nuclear respiratory factor 2 subunit alpha.
Gene name:  GABPA
Family name: ETS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 1
GENE REF ISO

Function

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Overview 
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAMGI
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDABHF-UCL
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAMGI
GO biological process 
Cell differentiationdefinition[GO:0030154] silver  
  • IBARefGenome
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of megakaryocyte differentiationdefinition[GO:0045653] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IDAMGI
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Organelle biogenesis and maintenance  REACT_200751  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GABPA
GenomeRNAi: 2551
PRO: PR:Q06546