RAD51 - DNA repair protein RAD51 homolog 1 - human protein (Function)
 
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RAD51 »  DNA repair protein RAD51 homolog 1  (HsRAD51)
 
Protein also known as:  RAD51 homolog A.
Gene name:  RAD51
Family name: RecA » RAD51
Entry whose protein(s) existence is based on evidence at protein level
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1 330 4
GENE REF ISO

Function

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Overview 
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.  
9
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • MGI
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA polymerase bindingdefinition[GO:0070182]  
1
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • UniProtKB
Contributes to endodeoxyribonuclease activitydefinition[GO:0004520]  
1
  • RefGenome
Four-way junction DNA bindingdefinition[GO:0000400]  
1
  • RefGenome
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
Protein bindingdefinition[GO:0005515]  
39
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Recombinase activitydefinition[GO:0000150]  
1
  • RefGenome
Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • UniProtKB
Single-stranded DNA-dependent ATPase activitydefinition[GO:0043142]  
2
  • UniProtKB
GO biological process 
Cellular response to camptothecindefinition[GO:0072757]  
1
  • UniProtKB
Cellular response to cisplatindefinition[GO:0072719] silver  
1
  • Ortholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
2
  • UniProtKB
Cellular response to gamma radiationdefinition[GO:0071480] silver  
1
  • Ortholog Compara
Cellular response to hydroxyureadefinition[GO:0072711] silver  
1
  • Ortholog Compara
Cellular response to ionizing radiationdefinition[GO:0071479]  
2
  • UniProtKB
Chromosome organization involved in meiotic cell cycledefinition[GO:0070192]  
1
  • RefGenome
DNA recombinationdefinition[GO:0006310]  
1
  • UniProtKB
DNA unwinding involved in DNA replicationdefinition[GO:0006268]  
1
  • UniProtKB
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
3
  • UniProtKB
  • MGI
Homologous recombination-dependent replication fork processingdefinition[GO:1990426] silver  
1
  • InterPro 2 GO
Meiotic nuclear divisiondefinition[GO:0007126]  
1
  • Ortholog Curator
Mitotic recombinationdefinition[GO:0006312]  
1
  • PINC
Positive regulation of DNA ligationdefinition[GO:0051106]  
1
  • UniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • UniProtKB
Reciprocal meiotic recombinationdefinition[GO:0007131]  
1
  • PINC
Regulation of double-strand break repair via homologous recombinationdefinition[GO:0010569]  
1
  • UniProtKB
Regulation of protein phosphorylationdefinition[GO:0001932] silver  
1
  • Ortholog Compara
Replication fork processingdefinition[GO:0031297]  
1
  • UniProtKB
Replication-born double-strand break repair via sister chromatid exchangedefinition[GO:1990414] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to etoposidedefinition[GO:1902521] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Response to X-raydefinition[GO:0010165] silver  
1
  • Ortholog Compara
Strand invasiondefinition[GO:0042148]  
1
  • RefGenome
Telomere organizationdefinition[GO:0032200] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fanconi anemia pathway  hsa03460+5888  
Homologous recombination  hsa03440+5888  
Pancreatic cancer  hsa05212+5888  
Pathways in cancer  hsa05200+5888  
According to Reactome, this protein belongs to the following pathways:
HDR through Homologous Recombination (HRR)  R-HSA-5685942  
HDR through Single Strand Annealing (SSA)  R-HSA-5685938  
Homologous DNA Pairing and Strand Exchange  R-HSA-5693579  
Meiotic recombination  R-HSA-912446  
Presynaptic phase of homologous DNA pairing and strand exchange  R-HSA-5693616  
Resolution of D-loop Structures through Holliday Junction Intermediates  R-HSA-5693568  
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)  R-HSA-5693554  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAD51
GenomeRNAi: 5888
PRO: PR:Q06609