PAX8 - Paired box protein Pax-8 - human protein (Function)
 
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PAX8 »  Paired box protein Pax-8
 
Gene name:  PAX8
Entry whose protein(s) existence is based on evidence at protein level
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1 30 5
GENE REF ISO

Function

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Overview 
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
3
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
Thyroid-stimulating hormone receptor activitydefinition[GO:0004996]  
1
  • TASPINC
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • IEPUniProtKB
Cellular response to gonadotropin stimulusdefinition[GO:0071371]  
1
  • IDAUniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • IEPUniProtKB
Inner ear morphogenesisdefinition[GO:0042472]  
  • ISSOrtholog Curator
Kidney developmentdefinition[GO:0001822]  
1
  • IEPUniProtKB
Mesenchymal to epithelial transition involved in metanephros morphogenesisdefinition[GO:0003337]  
1
  • IEPUniProtKB
Mesonephric tubule developmentdefinition[GO:0072164] silver  
  • IEAOrtholog Compara
Mesonephros developmentdefinition[GO:0001823]  
  • ISSOrtholog Curator
Metanephric comma-shaped body morphogenesisdefinition[GO:0072278]  
1
  • IEPUniProtKB
Metanephric distal convoluted tubule developmentdefinition[GO:0072221]  
  • ISSOrtholog Curator
Metanephric epithelium developmentdefinition[GO:0072207]  
1
  • IEPUniProtKB
Metanephric nephron tubule formationdefinition[GO:0072289]  
  • ISSOrtholog Curator
Metanephric S-shaped body morphogenesisdefinition[GO:0072284]  
1
  • IEPUniProtKB
Negative regulation of apoptotic process involved in metanephric collecting duct developmentdefinition[GO:1900215]  
  • ISSOrtholog Curator
Negative regulation of apoptotic process involved in metanephric nephron tubule developmentdefinition[GO:1900218]  
  • ISSOrtholog Curator
Negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesisdefinition[GO:0072305]  
  • ISSOrtholog Curator
Negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentdefinition[GO:1900212]  
  • ISSOrtholog Curator
Otic vesicle developmentdefinition[GO:0071599]  
1
  • IEPUniProtKB
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
  • ISSOrtholog Curator
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisdefinition[GO:0072108]  
  • ISSOrtholog Curator
Positive regulation of metanephric DCT cell differentiationdefinition[GO:2000594]  
  • ISSOrtholog Curator
Positive regulation of thyroid hormone generationdefinition[GO:2000611]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IDAUniProtKB
  • ISSOrtholog Curator
Pronephric field specificationdefinition[GO:0039003]  
  • ISSOrtholog Curator
Pronephros developmentdefinition[GO:0048793]  
  • ISSOrtholog Curator
Regulation of apoptotic processdefinition[GO:0042981]  
  • ISSOrtholog Curator
Regulation of metanephric nephron tubule epithelial cell differentiationdefinition[GO:0072307]  
  • ISSOrtholog Curator
Regulation of thyroid-stimulating hormone secretiondefinition[GO:2000612]  
1
  • IMPUniProtKB
Thyroid gland developmentdefinition[GO:0030878]  
3
  • IEPUniProtKB
Thyroid-stimulating hormone signaling pathwaydefinition[GO:0038194]  
1
  • TASGOC
Transcription, DNA-templateddefinition[GO:0006351]  
2
  • IDAUniProtKB
Urogenital system developmentdefinition[GO:0001655]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pathways in cancer  hsa05200+7849  
Thyroid cancer  hsa05216+7849  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PAX8
GenomeRNAi: 7849
PRO: PR:Q06710